Moderate to severe ME/CFS and POTS, somewhat better with LDN and CoQ10
- Condition
- ME/CFS
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- 5.5 years
- Last post
- Sep 2026
In their words
- Condition: ME/CFS
I got CFS and POTS after taking the original series of Pfizer in May 2021.
In context ↗ - At worst: Moderate
The Pfizer vaccine sent me from very mild to moderate/severe
In context ↗ - Now: Somewhat better
Still suffering from these but some treatments are starting to help.
In context ↗ - Began after: a vaccination
I got CFS and POTS after taking the original series of Pfizer in May 2021.
In context ↗
Read from 18 of their posts and comments; links to the 12 this page draws on
Summary
Cove 18566 developed CFS and POTS after the original Pfizer COVID vaccination series in May 2021, going from very mild to moderate or severe. MitoQ, CoQ10, NAC and phosphatidyl choline gave small or noticeable energy gains, low-dose naltrexone was helpful, Paxlovid got them through a COVID infection and a Novavax booster was tolerated. They were still using CFS treatments in 2026, and microdosed semaglutide made them worse.
Ask Miruvor AI
What they tried
What they credit
Also tried
Their words about each treatment
- mitoq · Helped
I used mitoq for several years, first at the standard dose and then increasing to 1.5 dose for extra benefit.
In context ↗ - coq10 · Helped
I switched to coq10 which I take at double dose, and the benefit is the same for me as the mitoq but cheaper.
In context ↗ - paxlovid · Helped
I did that when I got COVID just in case the COVID might make my cfs worse. Paxlovid worked like a charm.
In context ↗ - NAC · Helped
Coq10, NAC, and phosphatidyl choline all gave me a small but noticable energy boost.
In context ↗ - low dose naltrexone · Helped
He prescribed low dose naltrexone which has been helpful for me.
In context ↗ - Wellbutrin · Not said
I have also tried Wellbutrin at 75 and 100 mg. Not sure if it helps, I need to try it some more.
In context ↗ - head raising of bed · Not said
I worked my way up to 5 inch but 8 inch was too much and triggered my orthostatic intolerance.
In context ↗ - b12 shots · Helped
I get numbness in my hands and feet when I'm low in b12. ... I find I need to get the shots every three weeks. I had the doctor show me how to do them at home.
In context ↗ - nicotine patches · No change
Cut. But didn't see a benefit from the patches.
In context ↗ - semaglutide · Worse
I got microdosed semaglutide through ageless rx telehealth. I started with much less than the prescribed microdose, but it made me feel worse, and I was losing weight even on the tiny dose which I didn't want.
In context ↗ - COVID vaccination as treatment · Worse
The Pfizer vaccine sent me from very mild to moderate/severe
In context ↗
Approaches: Supplements
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| May 2021 | Pfizer COVID vaccination series triggered CFS and POTSI got CFS and POTS after taking the original series of Pfizer in May 2021.In context ↗ | Moderate | |
| 2023-10-16 | some treatments starting to helpStill suffering from these but some treatments are starting to help.In context ↗ | Moderate | |
| 2024-10-23 | low-dose naltrexone helpful for fatigueHe prescribed low dose naltrexone which has been helpful for me.In context ↗ | Moderate | Low-dose naltrexone |
| 2026-05-23 | felt improved at 7.5 mg LDNI was on 5, but accidentally messed up and took 7.5 for a few days and felt improved.In context ↗ | Moderate | Low-dose naltrexone |
| 2026-09-29 | microdosed semaglutide made them feel worseI started with much less than the prescribed microdose, but it made me feel worse, and I was losing weight even on the tiny dose which I didn't want.In context ↗ | Moderate |
Adverse events
- COVID vaccination as treatment“The Pfizer vaccine sent me from very mild to moderate/severe” In context ↗ Made symptoms worse
- “8 inch was too much and triggered my orthostatic intolerance” In context ↗ Made symptoms worse
- Semaglutide (Ozempic, Wegovy)“it made me feel worse, and I was losing weight even on the tiny dose” In context ↗ Made symptoms worse
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
Sometimes I get numbness from PEM too, but it is dominated by other PEM symptoms.
In context ↗ - POTS & dysautonomia
I got CFS and POTS after taking the original series of Pfizer in May 2021.
In context ↗ - Neuropathy & tingling
I get numbness in my hands and feet when I'm low in b12.
In context ↗
Ask Miruvor AI
Similar stories
-
Severe, housebound ME/CFS, somewhat better with pacing and low-dose naltrexone
A UK woman ill with ME/CFS for eight years, severe and housebound since 2021 after graded walks left her wheelchair dependent. She credited pacing and low-dose naltrexone with steady gains, and later a low-histamine diet with curing insomnia, migraines,…
-
Severe ME/CFS with PEM and POTS; improved on Q10, then relapsed
Alder 79374 has severe ME/CFS with PEM and POTS. Q10 first took them from severe to moderate, but the benefit faded after about six months. They credit LDN, Q10, NAC, famotidine and ketotifen with helping. DBT and vagal stimulation help a little, and they…
-
Bedbound with ME/CFS, now much better and working part-time after rest and LDN
Diagnosed with ME/CFS in 2017, they were very severe and bedbound for about two years around 2024, unable to eat, sit up or tolerate light and sound. They credit total rest, low-dose naltrexone (up to 4.5 mg twice daily), Effexor, a vagus nerve device,…
-
Severe ME/CFS with POTS, now somewhat better after cervical traction and Mestinon
Gradual ME/CFS onset around puberty; neck instability in their mid-20s left them severe with hyperadrenergic POTS, mast cell disease and gastroparesis. Cervical traction and PT took them from severe to moderate, and with Mestinon from worse-end moderate to…