Long COVID exhaustion and brain fog, much better with methylene blue and Glialia
- Condition
- Long COVID
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- 3 years
- Last post
- Oct 2026
In their words
- Condition: Long COVID
It has restored my mental faculties massively after 3 years of brain fog.
In context ↗ - At worst: Moderate
I was exhausted to the point of feeling the same way
In context ↗ - Now: Much better
Still on all of it but with everything I feel 70-80% recovered depending on the day. Still gotta pace myself though
In context ↗ - Began after: COVID
my last round of actual covid being 2-3 years ago
In context ↗ - Says they never had: Headaches & migraine
I don't really have headaches or dizziness
Read from 41 of their posts and comments; links to the 23 this page draws on
Summary
Gull 64342 has had long COVID since about 2023, with brain fog, post-exertional malaise, anhedonia and gut problems, and at worst had rough exhaustion. Methylene blue, started around 2024, helped most, easing fatigue and sleep and getting them back to waiting tables three or four nights a week. Glialia, an imported Italian supplement, cleared most of their brain fog after about a month of taking it, though PEM and anhedonia persisted.
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What they tried
What they credit
Also tried
Their words about each treatment
- gluten free and dairy free diet · No change
I've been gluten free and dairy free for almost 10 years and I still right stomach issues every day.
In context ↗ - Vitamin D3 · Helped
finally got some 50k IU D3 weekly pills from my Dr that actually keep my blood levels reasonable
In context ↗ - ECT · No change
I did 12 treatments. Didn't really help my depression, plus it was absolutely terrible to deal with afterwards.
In context ↗ - Methylene Blue · Helped a lot
I take it daily. 15 mg in the morning, 15 mg before sleep.
In context ↗ - oxytocin · Helped
I tried oxytocin and it helps a little bit but it doesn't replace the missing chemicals.
In context ↗ - H1 antihistamine (allergy kind) · Helped
Also both kinds of antihistamine medication, the allergy kind and the heartburn kind, H1 and H2 receptor antagonists.
In context ↗ - fish oil · Helped
Also fish oil, magnesium, coq10 all help me a lot
In context ↗ - peptides (Semax and other high boosting peptides) · Not said
I've been on a variety of high boosting peptides with no real changes for last 2 years.
In context ↗ - Nicotine Patches · Helped
On days I'm waiting tables I also use nicotine patches
In context ↗ - Glialia · Helped a lot
It took me a month on it before it really started working then it cleared up my brain fog by 80-90%.
In context ↗ - NAD shots · Helped
I use NAD shots too and that really helps with the inflammation
In context ↗ - tryptophan · Helped
I take tryptophan every night and it definitely helps but it's not fixing my anhedonia at all.
In context ↗ - bupropion · Not said
I'm on buproprion too and I'm not sure it's helping at all, definitely not fixing the anhedonia.
In context ↗ - melatonin · Helped
I've taken up to 50mg in a night before and woke up feeling fully rested and great.
In context ↗ - sugar and caffeine · Not said
a steady drip of sugar and caffeine as needed
In context ↗ - B12 shots · Not said
I'm still doing B12/NAD+ shots at home 2x per week.
In context ↗ - psyllium husk · Worse
easier on the stomach than I found psyllium husk to be
In context ↗ - Objective Nutrients Better GI Mucosal Barrier Support · Helped
It has definitely helped me in terms of calming down my gut issues and slowing my stomach down.
In context ↗
Approaches: H1 antihistamines · H2 blockers · Other drugs and medicines · Supplements
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. The chart starts 20 months after onset: the story doesn’t say how ill they were before that. 1 step says too little to place on the scale and is only in the table. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were |
|---|---|---|
| 2023 | COVID infection, followed by long COVIDmy last round of actual covid being 2-3 years agoIn context ↗ | Not stated |
| 2025 | exhausted, brain fog, crashes after overdoing itI was exhausted to the point of feeling the same wayIn context ↗ | Moderate |
| 2025-07 | methylene blue eased fatigue and restored refreshing sleepMethylene Blue is seriously helping me ... it's giving me my life back after 2 yearsIn context ↗ | Mild |
| 2026-01 | exercising several times a week and back to waiting tables three nights a weekI'm up to exercising multiple times a week and working three nights a week waiting tables againIn context ↗ | Mild |
| 2026-04 | most of the brain fog clearedIt has restored my mental faculties massively after 3 years of brain fog ... most days I'm at 80% or betterIn context ↗ | Mild |
| 2026-05 | 50-60% functional and working three or four days a weekNow I'm 50-60% functional again and working 3-4 days a weekIn context ↗ | Mild |
Adverse events
- Electroconvulsive therapy (ECT)“I did 12 treatments. Didn't really help my depression, plus it was absolutely terrible to deal with afterwards.” In context ↗ Side effects
- Psyllium husk (Metamucil)“easier on the stomach than I found psyllium husk to be” In context ↗ Gut side effects
Symptoms mentioned
Their words about their symptoms
- Brain fog
I still have some brain fog and memory issues
In context ↗ - Post-exertional malaise
So far nothing is helping the PEM and the anhedonia
In context ↗ - Anxiety & low mood
Brain fog, post exertion malaise, severe anhedonia
In context ↗ - Sleep problems
I take 6 extra strength Olli sleep gummies to sleep 8 hours every night
In context ↗ - Gut problems
I have a lot of gas and bloating issues
In context ↗ - Temperature regulation
I'm definitely much more cold sensitive than I used to be
In context ↗
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