Housebound with long COVID for two years, somewhat better after low-dose naltrexone
- Condition
- Long COVID
- At worst
- Severe (mostly bedbound)
- Ill before improving or writing
- 3 years
- Last post
- Mar 2026
In their words
- At worst: Severe
I could hardly walk most days ... I could hardly wash my own hair
In context ↗ - Now: Somewhat better
I'm not 100% recovered but I'm no longer house bound.
In context ↗
Read from 25 of their posts and comments; links to the 12 this page draws on
Summary
They got COVID in 2021 and have long COVID; they were largely housebound for two years, some days nearly bedbound, with ME/CFS, fibromyalgia, MCAS and POTS. Low-dose naltrexone in late 2024 eased brain fog, pain and energy within a day; metformin, progesterone, glutathione and a spike-protein supplement also helped. By March 2026 they were no longer housebound but still not fully recovered; they had reported being disabled and unable to climb stairs or stand for long.
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What they tried
What they credit
Also tried
Their words about each treatment
- Adderall · Helped
I have 20 mg instant release and only take 5-10 mgs when I need it. It does (with or without added exertion) make my fibromyalgia flare almost every time
In context ↗ - daily affirmation and visualization · Not said
I truly feel it supported preparing my mind and body to begin taking it. And if nothing else, it most certainly didn’t hurt anything!
In context ↗ - Low Dose Naltrexone · Helped a lot
low dose naltrexone has improved my life so much- (definitely recomend checking out that sub if you’re curious) within 24 hours I had Less brain fog, more energy, better mobility, less pain.
In context ↗ - Ultimate Spike Detox by the Wellness Company · Helped
This is the product I’ve been taking for months and it does help me. I feel better overall, symptoms are less severe.
In context ↗ - low histimine diet · Helped
All my fevers stopped when I started a low histimine diet for the MCAS.
In context ↗ - metformin · Helped
This month I started taking metformin and I already see improvement ... I tolerate great- no side effects, only improvements. 500 mg ER 24 hour
- glutathione · Helped
Glutathione has also been good for supporting mitochondria
In context ↗ - progesterone · Helped
started taking progesterone on days 14-28 of my cycle and that seems to be reducing the severity of my symptoms during my luteal phase
In context ↗ - psylocibin · Helped
As daily maintenance LDN and psylocibin have moved the improved my condition more over time for brain fog and capacity.
In context ↗ - tirzepetide · Not said
Recently added tirzepetide after the new study came out from Scripps finding efficacy in long COVID management. I’m not 100% recovered but I’m no longer house bound.
In context ↗ - COVID vaccination as treatment · Worse
had my most severe long covid decline post vaccine
In context ↗
Approaches: Other drugs and medicines · Sex hormones · Supplements
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. The chart starts 3 years after onset: the story doesn’t say how ill they were before that. 2 steps say too little to place on the scale and are only in the table. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| 2021 | COVID infection; long COVID beganI did not have any autoimmune disfunction before getting Covid in 2021In context ↗ | Not stated | |
| — | severe decline after a COVID vaccinehad my most severe long covid decline post vaccineIn context ↗ | Not stated | |
| 2024-11 | mostly housebound, some days almost bedboundI’ve been disabled for 2 years, mostly home bound, some days almost bed boundIn context ↗ | Severe | |
| 2024-11-16 | LDN started; less brain fog, more energy, less pain, went to an eventI started 0.75 mg of LDN 2 weeks ago and I feel better than I have in over a yearIn context ↗ | Moderate | Low-dose naltrexone |
| 2025-10-23 | metformin added; more usable hours, almost no brain fog, no POTS lightheadednessI have way more energy and usable hours in a day, almost zero brain fog and I am no longer light headed from POTSIn context ↗ | Moderate | Metformin |
| 2026-03-19 | no longer housebound but still disabled; cannot climb stairs or stand longI’m not 100% recovered but I’m no longer house boundIn context ↗ | Moderate |
Adverse events
- COVID vaccination as treatment“had my most severe long covid decline post vaccine” In context ↗ Made symptoms worse
- Amphetamine salts (Adderall)“It does (with or without added exertion) make my fibromyalgia flare almost every time” In context ↗ Made symptoms worse
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
I sometimes fear exertion bc of my PEM and a potential CFS flare up
In context ↗ - Brain fog
No more brain fog only short flare ups every few months maybe
In context ↗ - POTS & dysautonomia
I am no longer light headed from POTS
In context ↗ - Mast cell (MCAS) & allergies
Still have all my MCAS and fibro issues
In context ↗ - Pain & fibromyalgia
I have fibromyalgia so it’s full body and it has helped full body
In context ↗ - Light & noise sensitivity
Every stimulus I encountered deteriorated me further, every sound, every word spoken, every light.
In context ↗ - Muscle weakness
Some days my muscles would lock up and almost give out, I could hardly wash my own hair.
In context ↗ - Gut problems
very regular digestive system and no more stomach aches
In context ↗ - Flu-like symptoms
All my fevers stopped when I started a low histimine diet for the MCAS.
In context ↗ - Temperature regulation
nothing touches my heat intolerance but LDN made everything else better
In context ↗
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