Long COVID
Outcome unclear
Long COVID: 3am pounding heart, brain fog and PEM; midodrine helped, glutathione potent
- Condition
- Long COVID
- At worst
- Not stated
- Ill for
- Not stated
- Last post
- Aug 2026
In their words
- Condition: Long COVID
I'm drinking lots of water, wearing compression socks, and increasing salt intake. Not cutting it.
In context ↗
Read from 13 of their posts and comments; links to the 11 this page draws on
Summary
Gull 45306 reports waking at 3am with a pounding heart, low blood pressure and a 50-60 bpm rate, plus brain fog and PEM. Salt, fluids and compression did not help. Midodrine was a major help; qi gong felt better than yoga, and ergothioneine, urolithin A and MA-5 gave mild gains, while intranasal glutathione was potent for brain fog and energy. IHHT triggered PEM, and SS-31 and LDN had done nothing so far.
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What they tried
Also tried
Midodrine· Helped a lotintranasal liposomal glutathione· Helped a lotergothioneine· Helpedqi gong· HelpedMA-5· Helpedurolithin A· Helpedwater, compression socks, salt· No changewater, compression socks, salt· No changefunctional medicine doctor· No changeSS-31· No changeLDN· No changeIHHT with oxygen concentrator· Worseteaspoon of honey· Not saidweighted blanket· Not saidregular sleep schedule, cold room, no screens· Not saidyoga· Not said
Their words about each treatment
- water, compression socks, salt · No change
I'm drinking lots of water, wearing compression socks, and increasing salt intake. Not cutting it.
In context ↗ - teaspoon of honey · Not said
I've tried extra hydration, teaspoon of honey, weighted blanket, regular sleep schedule, cold room, no screens 2 hours before, etc.
In context ↗ - IHHT with oxygen concentrator · Worse
I have an oxygen concentrator and was attempting IHHT but that was last year and I couldn't do it without experiencing PEM.
In context ↗ - ergothioneine · Helped
I've been on it for two months and seems to help a bit. No drawbacks.
In context ↗ - qi gong · Helped
I've been doing some for just a week now and it feels better than yoga.
In context ↗ - Midodrine · Helped a lot
Midodrine is a major help for me, I can tell when I need to take it again because I just don't feel like doing anything but sitting.
In context ↗ - functional medicine doctor · No change
I tried it briefly as well and was initially optimistic but ultimately there wasn't much improvement from the treatments.
In context ↗ - SS-31 · No change
I tried 6 weeks of SS-31 5mg/day. Unfortunately I didn't notice anything.
In context ↗ - LDN · No change
I'm also titrating up my LDN dose. I'm at 1.5mg. Haven't noticed anything yet but am hopeful once I get up to 3mg or so.
In context ↗ - MA-5 · Helped
Started MA-5 a week ago. Seems to help a bit with energy but not in a chatecholamine way.
In context ↗ - urolithin A · Helped
I just hopped on Urolithin A two weeks ago and it's in my top 5 of actually noticeable substances.
In context ↗ - intranasal liposomal glutathione · Helped a lot
I've found intranasal liposomal glutathione to be very potent for clearing brain fog and lending energy.
In context ↗
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | Where they were | After |
|---|---|---|---|
| 2024-05-10 | already ill; waking at 3am with a pounding heart, low blood pressure and broken sleepUsually waking up at 3am with my heart pounding but low bpm 50-60 and lowish bp 90. Can't get back to sleep for an hour or two.In context ↗ | Mild | |
| 2025-07-09 | a week of qi gong felt better than yogaI've been doing some for just a week now and it feels better than yoga.In context ↗ | Mild | Qigong, tai chi and isometric yoga |
| 2025-07-15 | midodrine a major help, wearing off between dosesMidodrine is a major help for me, I can tell when I need to take it again because I just don't feel like doing anything but sitting.In context ↗ | Mild | Midodrine |
| 2026-05-11 | MA-5 seemed to help a bit with energyStarted MA-5 a week ago. Seems to help a bit with energy but not in a chatecholamine way.In context ↗ | Mild | |
| 2026-05-20 | urolithin A among the most noticeable substancesYeah I just hopped on Urolithin A two weeks ago and it's in my top 5 of actually noticeable substances.In context ↗ | Mild | |
| 2026-08-08 | MA-5 among the few helpful substances but overstimulatingIf you can get it, ma5 is amongst the select few substances I've found to be helpful.In context ↗ | Mild |
Adverse events
- “I have an oxygen concentrator and was attempting IHHT but that was last year and I couldn't do it without experiencing PEM.” In context ↗ Made symptoms worse
- “I find it a bit overstimulating but that's much much more a reflection of me than ma5.” In context ↗ Side effects
Symptoms mentioned
Their words about their symptoms
- POTS & dysautonomia
waking up at 3am with my heart pounding but low bpm 50-60 and lowish bp 90
In context ↗ - Heart symptoms & palpitations
with my heart pounding
In context ↗ - Sleep problems
Can't get back to sleep for an hour or two.
In context ↗ - Brain fog
intranasal liposomal glutathione to be very potent for clearing brain fog
In context ↗ - Post-exertional malaise
I couldn't do it without experiencing PEM
In context ↗