Six years of long COVID, unable to stand 20 minutes, now somewhat better on tirzepatide
- Condition
- Long COVID
- At worst
- Mild (working or studying, with limits)
- Ill before improving or writing
- 6 years
- Last post
- Aug 2026
In their words
- Condition: Long COVID
I've been a Covid long hauler for six years now
In context ↗ - At worst: Mild
Couldn't stand up for more than 20 minutes straight ... I put all my energy into my job and spent every weekend at home recovering
In context ↗ - Now: Somewhat better
I started to see my energy levels were improving. Like by a lot ... I've had it for 6+ years so I feel like this is just my life now
- Began after: COVID
I've been a Covid long hauler for six years now
In context ↗ - Says they never had: Loss of smell or taste
I was one of the fortunate ones who didn't have that side effect (of losing taste or smell).
Read from 21 of their posts and comments; links to the 7 this page draws on
Summary
Pebble 23775 had long COVID for six years, keeping their job but spending every weekend recovering and unable to stand for more than 20 minutes. Micro-dosed semaglutide made them badly nauseous, so they switched to tirzepatide at 1.25 mg, which they credit with lifting their energy, sleep and joint pain. By mid-2026 they were much better but still considered themselves living with long COVID and expected to stay on the drug, about $200 a month.
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What they tried
What they credit
Also tried
Their words about each treatment
- Vitamins and supplements · No change
I tried so many things with little to no success. Alllllll the vitamins and supplements
In context ↗ - hormone replacement therapy · No change
I tried so many things with little to no success ... hormone replacement therapy
In context ↗ - homeopathic doctor protocols · No change
I tried so many things with little to no success ... homeopathic doctor protocols
In context ↗ - special diets · No change
I tried so many things with little to no success ... special diets
In context ↗ - nicotine patches · No change
I tried so many things with little to no success ... nicotine patches
In context ↗ - semaglutide · Worse
I started out on Noom and was micro-dosing semaglutide ... I was so incredibly sick every day from that medication.
In context ↗ - tirzepatide · Helped a lot
once I got through that, I started to see my energy levels were improving. Like by a lot.
In context ↗ - Advil · Not said
I went everywhere with my heating pad and took a lot of Advil on the regular
In context ↗ - Miralax · Helped
My fix to this, which has worked really well for me, is to take a cap full of Miralax mixed into cranberry juice every other night with dinner.
In context ↗ - Wellbutrin · Helped
I am on Wellbutrin (really low dose 150SR just once in the morning). I do believe it helped
In context ↗ - Zofran · Helped
They do prescribe (at least where I went through) zofran which helps a bunch. I haven't needed it after the initial two weeks
In context ↗ - LDN · Worse
I actually did try LDN and it made me so anxious I felt like my heart was going to pound out of my chest.
In context ↗
Approaches: GLP-1 drugs
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. The first step with a time is 6 years after onset: the story doesn’t say how ill they were before that. The dashed part: the story doesn’t say when. 2 steps say too little to place on the scale and are only in the table. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were |
|---|---|---|
| 2020 | long COVID after COVID-19I've been a Covid long hauler for six years nowIn context ↗ | Not stated |
| — | working but every weekend spent at home recovering, could not stand 20 minutesI put all my energy into my job and spent every weekend at home recovering, just to get ready to go back to workIn context ↗ | Mild |
| — | crashed after simple chores and was bed bound for daysAny time I would do anything, even simple things like clean the house, it'd send me in a flare and I would have to be bed bound for multiple days.In context ↗ | Severe |
| 2026 | severely sick on semaglutide for nearly a monthI lasted just shy of a month before switching because I was so incredibly sick every day from that medication.In context ↗ | Not stated |
| 2026-05-07 | energy up by a lot, no more daily crashes, sleep and joint pain much betterI started to see my energy levels were improving. Like by a lot.In context ↗ | Mild |
| 2026-06-15 | still on 1.25 mg tirzepatide, still living with long COVIDI've had it for 6+ years so I feel like this is just my life nowIn context ↗ | Mild |
Adverse events
- Semaglutide (Ozempic, Wegovy)“I lasted just shy of a month before switching because I was so incredibly sick every day from that medication. The worst nausea and stomach pains - it sucked.” In context ↗ Gut side effects
- Tirzepatide (Mounjaro, Zepbound)“My first week to two weeks there was definitely nausea, but it wasn't debilitating like it was for me on semaglutide.” In context ↗ Side effects
- Tirzepatide (Mounjaro, Zepbound)“I have experienced some GI upset, mainly constipation. My fix to this, which has worked really well for me, is to take a cap full of Miralax mixed into cranberry juice every other night” In context ↗ Gut side effects
- Low-dose naltrexone“I actually did try LDN and it made me so anxious I felt like my heart was going to pound out of my chest. I had to stop it after a couple of weeks” In context ↗ Mood or psychiatric effects
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
Any time I would do anything, even simple things like clean the house, it'd send me in a flare and I would have to be bed bound for multiple days.
In context ↗ - Brain fog
That's the best way I've heard to describe brain fog.
In context ↗ - Pain & fibromyalgia
My joint issues have improved so much it's hard to really put into words.
In context ↗ - Gut problems
I have experienced some GI upset, mainly constipation.
In context ↗ - Sleep problems
My sleep improved drastically, which I'm thinking is a direct correlation to the medication.
In context ↗ - Anxiety & low mood
I'm already an anxious person
In context ↗
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