Long COVID joint pain and exhaustion, a little better on low-dose tirzepatide
- Condition
- Long COVID
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- 3 years
- Last post
- Oct 2026
In their words
- At worst: Moderate
I feel like I can actually get stuff done, but the crash is too harsh that it's not worth it most of the time.
In context ↗ - Now: Somewhat better
I'm noticing a very small improvement in energy and brain fog
In context ↗
Summary
Lagoon 35294 had long COVID for three years, with overwhelming joint pain, slow recovery and exhaustion; daily panic attacks resolved after inner work. Quitting caffeine, alcohol and all supplements did not help, and occasional modafinil helped energy but brought harsh crashes. They began low-dose tirzepatide and four weeks in reported a very small improvement in energy and brain fog, with joint pain still fairly overwhelming.
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What they tried
What they credit
Also tried
Their words about each treatment
- tirz · Helped
I’m noticing a very small improvement in energy and brain fog
In context ↗ - modafinil · Helped
Only thing that helps is the very very random time I get a modafinil from my partner ... the crash is too harsh that it's not worth it most of the time.
In context ↗ - deep inner work · Helped
My daily panic attacks aren't around anymore thanks to some deep inner work
In context ↗ - quitting caffeine, alcohol · No change
Tried quitting caffeine, alcohol
In context ↗ - all of the supplements · No change
went on all of the supplements to no help
In context ↗
Approaches: GLP-1 drugs
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| 2023 (approx.) | long COVID began | |
| 2026-08-31 | overwhelming joint pain, exhaustion and poor recovery; panic attacks resolvedthe joint pain, recovery and exhaustion are awfulIn context ↗ | |
| 2026-10-02 | four weeks on titrated low-dose tirzepatide, very small gain in energy and brain fogI’m noticing a very small improvement in energy and brain fogIn context ↗ | Tirzepatide (Mounjaro, Zepbound) |
Adverse events
- Modafinil / armodafinil“I feel like I can actually get stuff done, but the crash is too harsh that it's not worth it most of the time.” In context ↗ Made symptoms worse
- Tirzepatide (Mounjaro, Zepbound)“I started at .25mg and found the side effects were more than I anticipated.” In context ↗ Side effects
Symptoms mentioned
Their words about their symptoms
- Pain & fibromyalgia
It’s honestly my joint pain that is still fairly overwhelming.
In context ↗ - Brain fog
I’m noticing a very small improvement in energy and brain fog
In context ↗ - Anxiety & low mood
My daily panic attacks aren't around anymore thanks to some deep inner work
In context ↗ - Sleep problems
if I've slept like absolute shit
In context ↗ - Post-exertional malaise
the crash is too harsh that it's not worth it most of the time
In context ↗
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