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Long COVID Moderate → relapsedIll 4 years before improving or writing

Long COVID with fatigue, POTS and brain fog, improved then relapsed after a virus

Condition
Long COVID
At worst
Moderate (mostly housebound)
Ill before improving or writing
4 years
Last post
Dec 2025
In their words
  • Condition: Long COVIDI’e had LC since May 2021 after my second COVID infection In context ↗
  • At worst: ModerateOCD symptoms rampant, terrible adrenaline surges paired with the worst brain fog known to man and crippling insomnia that had me staying up days at a time In context ↗
  • Now: RelapsedAs I have recovered from the virus all of my LC neuro symptoms have come screaming back In context ↗
  • Began after: COVIDI’e had LC since May 2021 after my second COVID infection that was worsened by a terrible reaction to sertraline in July of that year.
Read from 5 of their posts and comments; links to the 4 this page draws on

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Summary

Tulip 19721 developed long COVID in May 2021 after a second COVID infection, with fatigue, POTS, brain fog and anxiety, and a bad sertraline reaction that took 16 months to settle. He recovered after about 18 months, relapsed after an October 2023 reinfection and five days of walking 2.5 miles, then reached about 80% by spring 2024. A virus caught at a concert in late 2025 brought the neurological symptoms back.

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What they tried

Their words about each treatment
  • sertraline (Zoloft) · Much worseworsened by a terrible reaction to sertraline in July of that year In context ↗
  • exercise / walking 2.5 miles · Much worseI started exercising in mid-December, and experienced a terrible relapse after 5 days of walking 2.5 miles In context ↗

Their path

Very severeSevereModerateMildNear normalRecoveredonset12 mo2 y3 y4 y

How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. Dates are when they posted. What the levels mean.

Show as a table
WhenWhat happenedWhere they were
May 2021Long COVID after second COVID infectionI’e had LC since May 2021 after my second COVID infection ... my day to day symptoms weren’t terrible enough to keep me insideMild
July 2021bad reaction to sertraline (Zoloft)trust me when I say it was truly awful. Like, taking 16 months to bounce back awful. In context ↗Moderate
late 2022recovered after about a year and a halfI pretty much completely recovered after about a year and a half, after which I took a year to recuperate and just enjoy life again. In context ↗Near normal
October 2023reinfection with a week of diarrhea and brain fogI had about a week of diarrhea and awful brain fog return at the time, along with a very familiar COVID malaise. In context ↗Mild
December 2023 to January 2024terrible relapse after 5 days of walking 2.5 milesALL of my symptoms returned 10x worse, especially my anhedonia and neuro symptoms. In context ↗Moderate
April 2024relapse evened out and he reached about 80%Took about 3 months to even out, then about a month and a half of improvement until I was about 80%. In context ↗Mild
August 2024sleepless night followed by return of neuro symptomswoke up today and had a return of a good amount of neuro issues. Anhedonia, head pressure, tachycardia, the works. In context ↗Mild
June 2025mostly recovered with lingering symptomsWhile I say I’m “recovered”, that’s not entirely the case. In context ↗Mild
December 2025virus caught at a concert brought neuro symptoms backAs I have recovered from the virus all of my LC neuro symptoms have come screaming back. In context ↗Mild

Adverse events

  • Sertraline (Zoloft)“worsened by a terrible reaction to sertraline ... taking 16 months to bounce back awful” Side effects

Symptoms mentioned

Their words about their symptoms
  • Post-exertional malaiseexperienced a terrible relapse after 5 days of walking 2.5 miles In context ↗
  • Brain foghorrific Brain Fog In context ↗
  • POTS & dysautonomiafatigue, POTS, brain fog ... Currently dealing with fatigue, dizziness, anxiety, anhedonia again
  • Sleep problemsAnhedonia, DP/DR, Insomnia, and horrific Brain Fog In context ↗
  • Headaches & migraineAnhedonia, head pressure, tachycardia, the works In context ↗
  • Anxiety & low moodCurrently dealing with fatigue, dizziness, anxiety, anhedonia again In context ↗
  • BreathlessnessShortness of breath, mild insomnia and noticeable but not entirely debilitating brain fog plagued my days for a while. In context ↗
  • Gut problemsI had about a week of diarrhea and awful brain fog return at the time In context ↗
  • Flu-like symptomsalong with a very familiar COVID malaise In context ↗

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