ME/CFS
Moderate → no benefit
ME/CFS with brain fog and PEM; drugs and supplements brought no improvement
- Condition
- ME/CFS
- At worst
- Moderate (mostly housebound)
- Ill for
- Not stated
- Last post
- Oct 2026
In their words
- Condition: ME/CFS
But rawdogging mod-severe CFS is way rougher.
In context ↗ - At worst: Moderate
But rawdogging mod-severe CFS is way rougher.
In context ↗ - Now: No benefit
But nothing has brought me out of the worsening brought on by LC last year.
In context ↗ - Began after: nothing they could name
Only a year and a half in of being aware of it but have likely had it all my life.
In context ↗
Read from 18 of their posts and comments; links to the 14 this page draws on
Summary
Osprey 22307, in Canada, had likely had ME/CFS all their life and had been aware of it for about 18 months when writing, after long COVID worsened them. Nothing lifted that worsening; most drugs and supplements failed, including LDN, and controlling fatty liver and blood pressure moved brain fog only about 2%. Cannabis eased misery and ibuprofen pain, but both masked overexertion, and pushing through brought days or weeks of PEM.
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What they tried
Also tried
Their words about each treatment
- Cannabis (weed) · Helped
It’s legit the only thing that gets me through. ... weed, MVP.
In context ↗ - doxycycline · Worse
doxycycline made me nuts — off my rocker.
In context ↗ - 12-hour fast · Worse
I don’t eat for 12 hours and I get all the symptoms!
In context ↗ - cut back on sugar · Helped
cut back on sugar, and even got BP under control (when not standing). It’s probably moved the needle for my brain fog by a total of 2%
In context ↗ - Vitamin D · No change
Started 2500 about 10 days ago. No difference yet
In context ↗ - Prednisone · Worse
Prednisone used to help but since my ME and everything worsened last year due to Long Covid, it just blasted me into more misery.
In context ↗ - Pepcid · Worse
Starting 20mg. A week in, been largely negative.
In context ↗ - Ibuprofen · Helped
It lessens my pain but definitely don’t get more energy.
In context ↗ - Clonazepam · Helped
I’ve taken some from friends. Not a lot. Every time, some of the best peace of my life.
In context ↗ - basic daily tracking · Helped
Only use it for the basic daily tracking, and it has helped me see where I am and notice patterns.
In context ↗ - Lexapro · Helped
Lexapro for me makes it EASIER but far from any major improvement.
In context ↗ - LDN · No change
Also failed it. Was such a bummer, cause I was hoping maybe.
In context ↗
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. 1 step says too little to place on the scale and is only in the table. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were |
|---|---|---|
| — | ME/CFS likely present all their life, unaware for yearsOnly a year and a half in of being aware of it but have likely had it all my life.In context ↗ | Not stated |
| 2025 | worsened by long COVIDnothing has brought me out of the worsening brought on by LC last yearIn context ↗ | Moderate |
| 2026-10 | no improvement; LDN failed, propranolol and LDA next | Moderate |
Adverse events
- Doxycycline (Vibramycin)“doxycycline made me nuts — off my rocker.” In context ↗ Mood or psychiatric effects
- Cannabis (THC, marijuana)“oils stopped working like I got a sensitivity to them.” In context ↗ Side effects
- Corticosteroid pulses“it just blasted me into more misery. Honestly I can’t be entirely sure it didn’t worsen me.” In context ↗ Made symptoms worse
- Famotidine (Pepcid)“A week in, been largely negative.” In context ↗ Made symptoms worse
- Ibuprofen (Advil, Nurofen, Motrin)“it does and has tricked me and then I pushed it, and I get PEM.” In context ↗ Made symptoms worse
- Cannabis (THC, marijuana)“Helps mask, but if I push it, I will get PEM.” In context ↗ Made symptoms worse
- Cannabis (THC, marijuana)“it’s easy not to notice that you’ve overdone it (and then it punches you in the face maybe for days or weeks).” In context ↗ Made symptoms worse
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
if I push it, I will get PEM
In context ↗ - Brain fog
It’s probably moved the needle for my brain fog by a total of 2%
In context ↗ - Pain & fibromyalgia
But it’s def the best OTC for pain for me.
In context ↗ - POTS & dysautonomia
even got BP under control (when not standing)
In context ↗