Long COVID
Moderate → somewhat better
Long COVID fatigue and brain fog, somewhat better; guanfacine and NAC cleared much fog
- Condition
- Long COVID
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- years
- Last post
- Aug 2026
In their words
- Condition: Long COVID
crushing, life sucking fatigue and PEM
In context ↗ - At worst: Moderate
I can at least function at work these days
In context ↗ - Now: Somewhat better
Guanfacine + NAC helped tremendously with brain fog, but notttthinggggg has touched this horrific fatigue.
In context ↗
Read from 8 of their posts and comments; links to the 6 this page draws on
Summary
Years into long COVID they had crushing fatigue, PEM, brain fog and unrefreshing sleep while holding a demanding corporate job. Guanfacine extended release 1 mg at night with NAC 600 mg twice daily, prescribed by their neurologist, cleared much of the brain fog within days, but their short-term memory stayed poor and nothing touched the fatigue. They put themselves at about 75% of normal and still crashed by 3pm daily.
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What they tried
Their words about each treatment
- Guanfacine extended release · Helped a lot
Guanfacine extended release 1mg at night with NAC 600 mg twice a day cleared a ton of that brain fog for me
In context ↗ - NAC · Helped a lot
with NAC 600 mg twice a day cleared a ton of that brain fog for me - I felt the effects after the first couple of doses
In context ↗ - visible · No change
I’ve been using visible for about a month now, and I am disappointed with it
In context ↗
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| — | long COVID with fatigue, PEM and brain fog while working a demanding corporate jobthis crushing, life sucking fatigue and PEMIn context ↗ | Moderate | |
| 2025-10-13 | brain fog substantially better after first doses, able to function at workIt’s been about a month now and the difference in the brain fog is substantialIn context ↗ | Mild | Guanfacine |
| 2025-12-23 | symptoms settled, at about 75% of normalThings settled down now, and I’d say I’m at 75%ish of my normalIn context ↗ | Mild | Guanfacine |
| 2026-07-07 | one day feeling nearly normal after an unusually good night's sleepLike I feel nearly normal for the first time in yearsIn context ↗ | Near normal | |
| 2026-08-23 | brain fog much helped but crushing fatigue untouched; crashing at 3pm dailyI crash around 3pm every day and then just have to be horizontal for the rest of the dayIn context ↗ | Mild |
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
this crushing, life sucking fatigue and PEM
In context ↗ - Brain fog
I still struggle with short term memory
In context ↗ - Sleep problems
I sleep a ton, but am always exhausted bc it seems I don’t get enough deep sleep
In context ↗ - Headaches & migraine
Ahhhh I also have the one sided head pressure/weird feeling
In context ↗ - Neuropathy & tingling
then the vibrations and twitches started
In context ↗