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Long COVID Outcome unclear

Long COVID brain fog, tried low-dose naltrexone and stopped after side effects

Condition
Long COVID
At worst
Not stated
Ill for
Not stated
Last post
Jul 2025
In their words
  • Condition: Long COVIDit was just a lot of stuff that wasn't unfamiliar in LC-world In context ↗
Read from 1 of their posts and comments; links to the one this page draws on

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Summary

A Reddit user with long COVID tried low-dose naltrexone, starting very low and easing upward. Within a couple of weeks, at the second dose level, they felt generally unwell, slept badly, could not think, and had aches and headaches. They stopped it, and two days later came out of the fog, which they called one of the best feelings of their life, deciding with their provider not to restart.

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What they tried

Also tried

Their words about each treatment
  • LDN · Worseonly a couple weeks in, after only upping my dose to the second level, I had some things going on ... generally I was just not feeling well, wasn't sleeping well, couldn't think, aches, headaches In context ↗

Their path

They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.

WhenWhat happenedAfter
a couple weeks into low-dose naltrexone, at the second dose levelfelt worse after raising the LDN doseonly a couple weeks in, after only upping my dose to the second level, I had some things going on that were so non-specific, but generally I was just not feeling well In context ↗Low-dose naltrexone
day 2 after quitting LDNcame out of the fog after stopping LDNon day 2 after quitting it, it was like i woke from living underwater In context ↗Low-dose naltrexone

Adverse events

  • Low-dose naltrexone“I was just not feeling well, wasn't sleeping well, couldn't think, aches, headaches” In context ↗ Made symptoms worse
  • Low-dose naltrexone“only a couple weeks in, after only upping my dose to the second level, I had some things going on that were so non-specific ... wasn't sleeping well” In context ↗ Insomnia from treatment
  • Low-dose naltrexone“unable to get excited about things though i wasn't exactly depressed” In context ↗ Mood or psychiatric effects

Symptoms mentioned

Their words about their symptoms

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