Impact of extended-course Paxlovid in established Long COVID (Case 7)
- Condition
- Long COVID
- At worst
- Severe (mostly bedbound)
- Ill for
- 11 months
- Published
- 2023
Summary
Case 7, a 29-year-old man about 10 months into Long COVID/ME since July 2022 with extreme fatigue, PEM, tachycardia, POTS, persistent headache, brain fog, chest pain and shortness of breath, took a 15-day extended Paxlovid course in May 2023 while also on finasteride, amphetamine/dextroamphetamine salts, bupropion, atenolol, midodrine, vitamin D3 and famotidine. About six days in he had roughly 10% improvement in fatigue and brain fog that grew to about 20% by the end of the course, his longest symptom-free stretch since falling ill. Two days after his last dose he suffered a severe PEM crash and returned to his pre-Paxlovid baseline within five days, remaining there in the following months, so the gains did not hold.
What they credit
Credits POTS medication, Paxlovid, Antihistamines & MCAS, Supplements, Beta-blockers, H2 blockers (famotidine, cimetidine), Midodrine, Paxlovid / nirmatrelvir, Vitamin D and sun exposure.
Symptoms mentioned
Symptoms: Brain fog, Breathlessness, Headaches & migraine, Heart symptoms & palpitations, POTS & dysautonomia, Pain & fibromyalgia, Post-exertional malaise.
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