Long COVID fatigue and brain fog, improved on methylene blue then relapsed
- Condition
- Long COVID
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- 4 years
- Last post
- May 2026
In their words
- Condition: Long COVID
I acquired long covid 4 years ago, im a 63 year old male
In context ↗ - At worst: Moderate
I seldom left the house other than shopping which was exhausting.
In context ↗ - Now: Relapsed
slowly but I am not as good as i was back in the fall.
In context ↗ - Began after: COVID
I aquired covid back in jan 2021 before the vaccine became available. About a month later I ended up with long covid.
Read from 22 of their posts and comments; links to the 15 this page draws on
Summary
A man in his fifties got COVID in January 2021 and long COVID about a month later: fatigue, brain fog, burning hands and feet, lost taste, and he lost his IT job. Methylene blue, started mid-2025, took him from 3-4 to 8 out of 10, and he took a heavy physical cargo job. After it ended he crashed in January 2026 with insomnia, headaches and worse burning, and by May 2026 was only slowly improving. His savings were wiped out.
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What they tried
What they credit
Also tried
Their words about each treatment
- Pepcid A/C · No change
I started with Pepcid A/C and loratidine ... Nothing worked
In context ↗ - pedometer tracking / energy envelope · Helped
Basically track your energy levels, determine what is excessive (which you probably already know then gently push at your limits. This has helped me a great deal.
In context ↗ - CBD · Helped
I recently decided to give CBD a shot ... about a week or so after I started to use it my brain fog started to lift
In context ↗ - Vitamin D (D3 1000 IU) · Not said
I am taking Vitamin D (D3 1000 IU)
In context ↗ - Magnesium Citrate · Not said
Magnesium Citrate 500
In context ↗ - Brain Combo pill · Not said
Brain Combo pill (80mg rhodiola, 84 mg bocopa, 50mcg folate)
In context ↗ - red light therapy · No change
I have tried red light therapy which I supposed to be therapeutic ... none of them made any noticable difference
In context ↗ - SSRI · Not said
i quit the SSRI i was taking (I was due to quit)
In context ↗ - zopiclone · No change
Dr prescribed zopiclone and I was on it for 6 months and it was useless except if i stopped taking it I had worse insomnia
In context ↗ - melatonin · Helped
I ended up trying melatonin which helped for a while and then I tried Valarian.
In context ↗ - Valarian · Helped
then I tried Valarian. It has helped the most
In context ↗ - Methylene blue (MB) · Helped a lot
I started low, 1 drop, I dont take it everyday, usually everyother day. its been over 2 weeks and I am up to 3 drops.
In context ↗ - nattokinase · No change
Tried it for 2 weeks, didnt help, not in any way
In context ↗ - advil or tylenol · Helped
I would take advil or tylenol and lay down in the dark. This would help
In context ↗
Approaches: Other drugs and medicines
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. The chart starts 4 months after onset: the story doesn’t say how ill they were before that. 1 step says too little to place on the scale and is only in the table. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| January 2021 | COVID-19 infection; long COVID symptoms began about a month laterI aquired covid back in jan 2021 before the vaccine became available.In context ↗ | Not stated | |
| May 2021 | long COVID hit harder May to August; pushed through remote work and crashed each weeklast may the long covid hit harder, from may until Aug was toughIn context ↗ | Moderate | |
| October 2021 | lost job, three moves, every day doing too much and paying for itspent a month sorting, packing, cleaning, loading and unloading.In context ↗ | Moderate | |
| January 2022 | fatigue easing a little and brain fog lifting about a week after starting CBDI still have fatigue but it slowly seems to be getting better in the last couple of weeksIn context ↗ | Moderate | |
| March 2022 | energy up from 3-4 to 5-6 out of 10 by tracking energy and gently pushing at the limit2 months later I am at a 5-6 and progressing.In context ↗ | Moderate | Pacing and the energy envelope |
| January 2023 | major setback after pushing through Christmas, down to about 800 steps a dayAs a result I am now in a major setback, the worst I have felt in a year and a half.In context ↗ | Moderate | |
| July 2025 | methylene blue lifted energy, sleep and brain fog; rated himself 8 out of 10I have moved up to 8 out 10, I still have some symptoms but greatly reducedIn context ↗ | Mild | Methylene blue |
| November 2025 | took a heavy physical cargo job and 12-hour days; sore but made itit was brutal but I made it, I'm probably in the best shape ive been in decades.In context ↗ | Mild | Methylene blue |
| January 2026 | crashed after the physical jobs ended: insomnia, weakness, daily headaches, worse burningI crashed hard, I have bad insomnia, totally unproductive, feel weak and trouble focusingIn context ↗ | Moderate | |
| May 2026 | improving slowly after the crash but still below his autumn 2025 levelslowly but I am not as good as i was back in the fall.In context ↗ | Moderate |
Adverse events
- Methylene blue“when bumped up from 1 to 2 drops the first day I felt a little jumpy, jittery” In context ↗ Side effects
- Methylene blue“I did feel a little weird for an hour after I first took it” In context ↗ Side effects
- Zopiclone (Imovane)“Dr prescribed zopiclone and I was on it for 6 months and it was useless except if i stopped taking it I had worse insomnia” In context ↗ Withdrawal problems
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
I could go overboard to get things done but i would be wiped out for a couple of days afterwards (PEM).
In context ↗ - Brain fog
bad brain fog and fatigue which peaked from June to November
In context ↗ - Neuropathy & tingling
the burning feeling came back worse than ever
In context ↗ - Sleep problems
I have bad insomnia, totally unproductive, feel weak and trouble focusing
In context ↗ - Headaches & migraine
daily headaches (an ER doctor called them stress headaches and just prescribed Advil)
In context ↗ - Loss of smell or taste
Lost my sense of taste but it never properly recovered
In context ↗ - Temperature regulation
my feet at cold and burning at the same time
In context ↗ - Muscle weakness
feel weak and trouble focusing
In context ↗ - Pain & fibromyalgia
it was horrible, constant aches, backaches
In context ↗
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