Mostly housebound with ME/CFS, now much better with low-dose naltrexone and guanfacine
- Condition
- ME/CFS
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- Not stated
- Last post
- Sep 2026
In their words
- Condition: ME/CFS
I'm 90% convinced this is my CFS.
In context ↗ - At worst: Moderate
I was mostly housebound and some days in bed
In context ↗ - Now: Much better
On a positive note, guanfacine and LDN are what ultimately turned the tide. I have about 80% of my life back.
In context ↗
Read from 11 of their posts and comments; links to the 8 this page draws on
Summary
Lagoon 86315 was mostly housebound and some days in bed with CFS, after months of PEM from overdoing it on a winter break. Low-dose naltrexone, started in April 2026, cut PEM almost entirely, guanfacine helped sleep, and by late May they reported about 80% of their life back, biking 20 miles and working in person. Brain fog and short PEM remained; magnesium helped them sleep and function, and injected magnesium restored function for one to three days.
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What they tried
What they credit
Also tried
Their words about each treatment
- magnesium supplements (SlowMag, Calm powder) · Helped
It seems if I absolutely blast myself with it I can function again.
In context ↗ - IV magnesium / magnesium sulfate injections · Helped a lot
getting a magnesium IV completely reversed my crash face and made me look like I did in my 20s again for a day
In context ↗ - LDN · Helped a lot
I was mostly housebound and some days in bed and now I'm biking 20 miles at a time
In context ↗ - guanfacine · Helped a lot
It makes me feel like I'm ready to sleep instead of being wired but tired.
In context ↗
Approaches: Other drugs and medicines
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| January-April 2026 | months of PEM after overdoing it on winter breakThis was after being in PEM from basically January-April too from overdoing it on winter break.In context ↗ | Moderate | |
| April 2026 | mostly housebound with some days in bed, before LDNI was mostly housebound and some days in bedIn context ↗ | Moderate | |
| 2026-05-08 | 2.5 weeks into LDN: biking 20 miles, driving, working in personnow I'm biking 20 miles at a time, less scared to drive, and working in person again when askedIn context ↗ | Mild | Low-dose naltrexone |
| 2026-08-30 | functioning well with oral and injected magnesium, brain fog and short PEM remainif I absolutely blast myself with it I can function againIn context ↗ | Mild |
Adverse events
- Magnesium“I can't take enough magnesium supplements without stomach problems but they always make me feel significantly better. ... The problem is to get to that point almost always involves GI problems.” Gut side effects
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
Yesterday it seemed like it lasted 3-4 hours after working too hard but went away.
In context ↗ - Brain fog
I still get the brainfog and lack of focus.
In context ↗ - Sleep problems
It makes me feel like I'm ready to sleep instead of being wired but tired.
In context ↗ - Headaches & migraine
The exact same thing happened to me last November.
In context ↗ - Neuropathy & tingling
slightly numb fingertips or toes
In context ↗ - Pain & fibromyalgia
Jaw tension, neck stiffness
In context ↗
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