ME/CFS with muscle pain, neuropathy, brain fog, somewhat better on testosterone and rest
- Condition
- ME/CFS
- At worst
- Not stated
- Ill before improving or writing
- Not stated
- Last post
- Jun 2026
In their words
- Condition: ME/CFS
it's really helped my pem not last as long
In context ↗ - Now: Somewhat better
I've been on T just over a year and it's really helped my pem not last as long. I don't muscle waste as much anymore either.
In context ↗
Read from 6 of their posts and comments; links to the 6 this page draws on
Summary
A Reddit user with ME/CFS and undifferentiated connective tissue disease reported muscle pain, peripheral neuropathy and brain fog, and said PEM and muscle wasting eased after just over a year on testosterone. They credited radical rest, rehoming their pet, armodafinil for brain fog, B12 injections for neuropathy and Plaquenil for dryness. Top surgery two years earlier also improved their health.
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What they tried
What they credit
Also tried
Their words about each treatment
- armodafinil · Helped a lot
Low dose stimulant helped my brain fog immensely. I do 50mg armodafinil.
In context ↗ - radical rest · Helped
The concept of "radical rest" really helped me.
In context ↗ - rehoming my pet · Helped
Also, rehoming my pet. Taking him out throughout the day made me so much worse
In context ↗ - b12 injections · Helped
I do have some peripheral nueropathy, but b12 injections have been significantly minimizing it.
In context ↗ - Plaquinil · Helped
The Plaquinil has signifcantly helped with the extreme dryness though.
In context ↗ - T · Helped
I've been on T just over a year and it's really helped my pem not last as long. I don't muscle waste as much anymore either.
In context ↗ - top surgery · Helped
The top surgery got rid of this weird nerve brain zappy pain i used to get whenever i would touch something cold or wet.
In context ↗
Approaches: Radical rest · Sex hormones · Surgery & structural
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| 2026-05-24 | radical rest helped; rehomed pet because caring for it made them worseThe concept of "radical rest" really helped me. Also, rehoming my pet.In context ↗ | Radical rest |
| 2026-05-24 | armodafinil helped brain fog immenselyLow dose stimulant helped my brain fog immensely. I do 50mg armodafinil.In context ↗ | |
| 2026-06-25 | on testosterone just over a year: PEM shorter and less muscle wasting; earlier top surgery improved healthI've been on T just over a year and it's really helped my pem not last as long. I don't muscle waste as much anymore either.In context ↗ | Testosterone |
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
it's really helped my pem not last as long
In context ↗ - Brain fog
Low dose stimulant helped my brain fog immensely.
In context ↗ - Pain & fibromyalgia
I do have a lot of muscle pain, but no one has figured out really why.
In context ↗ - Neuropathy & tingling
I do have some peripheral nueropathy, but b12 injections have been significantly minimizing it.
In context ↗ - Muscle weakness
I don't muscle waste as much anymore either.
In context ↗
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