Long COVID with chronic pain and fatigue, much better after a combination of medications
- Condition
- Long COVID
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- 4 years
- Last post
- Oct 2026
In their words
- Condition: Long COVID
I've had it since June 2022
In context ↗ - At worst: Moderate
a mast cell stabilizer took me from couch bound to able to walk 30 mins
In context ↗ - Now: Much better
I went from being in pain 24/7 and having constant adrenaline rushes to now working remotely full time, strength training 3x a week and I'm slowly building up tolerance for upright cardio/walking
In context ↗ - Began after: COVID
clearly had this forever for covid 2022 ramped everything up
Read from 12 of their posts and comments; links to the 10 this page draws on
Summary
Crest 11710 has had long COVID since June 2022, with chronic muscle pain and fatigue on top of underlying hEDS. After four years of pushing through, a combination of propranolol, antihistamines, ketotifen, LDN and Mestinon eased 24/7 pain and constant adrenaline rushes. They now work remotely full time, strength train three times weekly and build up walking, though not in remission. Back-to-back infections in 2024 set them back.
Ask Miruvor AI
What they tried
What they credit
Also tried
Their words about each treatment
- pacing · Helped
The biggest things that have helped with pain for me personally are pacing, not pushing through pain
In context ↗ - LDN / low dose naltraxone · Helped
Low dose naltraxone has really helped with my baseline pain levels.
In context ↗ - physio · Helped
LDN and *slowly* doing physio to strengthen around my joints helped me the most.
In context ↗ - light resistance exercise every other day · Helped
I've also found light resistance exercise every other day helpful
In context ↗ - smart watch · Not said
I use a smart watch to track my HR
In context ↗ - compression and electrolytes · Helped
wear compression, drink electrolytes etc since I have dysautonomia that contributes to my fatigue
In context ↗ - time · Helped
Time and pacing. After my initial infection and reinfection it lasted about a year both times for me.
In context ↗ - propranolol · Helped
I just started propranolol and I've found the adrenaline is quieter day to day.
In context ↗ - ketotefin · Helped a lot
a mast cell stabilizer took me from couch bound to able to walk 30 mins
In context ↗ - antihistamines · Helped
I only noticed a subtle difference with antihistamines
In context ↗ - pepcid · Helped
The combo of antihistamines, pepcid, ketotefin, LDN, propranolol and mestonin has supported me to feel better
In context ↗ - mestonin · Helped
The combo of antihistamines, pepcid, ketotefin, LDN, propranolol and mestonin has supported me to feel better (though not in remission).
In context ↗
Approaches: H1 antihistamines · H2 blockers · POTS medication · Antihistamines & MCAS · Beta-blockers · Pacing · Physiotherapy and rehab
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. The chart starts 2.5 years after onset: the story doesn’t say how ill they were before that. 1 step says too little to place on the scale and is only in the table. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| June 2022 | long COVID after infection, on top of hEDSI've had it since June 2022.In context ↗ | Not stated | |
| 2024 | back-to-back cold, norovirus and a virusIt has been a year since these back to back infections and I am still crawling my way back to my previous baseline.In context ↗ | Moderate | |
| 2026 | pain 24/7, constant adrenaline rushes, quit the gym, couch boundI went from being in pain 24/7 and having constant adrenaline rushesIn context ↗ | Moderate | |
| March 2026 | adrenaline quieter on propranololI just started propranolol and I've found the adrenaline is quieter day to day. Now I'm just tired (yay?)In context ↗ | Mild | Propranolol (Inderal) |
| May 2026 | improved once on the right medicationsThings improved for me once I was able to access the right medications.In context ↗ | Mild | Ketotifen (Zaditen) |
| September 2026 | working full time remotely, strength training, building walking tolerancenow working remotely full time, strength training 3x a week and I'm slowly building up tolerance for upright cardio/walkingIn context ↗ | Mild |
Adverse events
- Propranolol (Inderal)“I just started propranolol and I've found the adrenaline is quieter day to day. Now I'm just tired (yay?)” In context ↗ Side effects
- Mestinon / pyridostigmine“Mestonin I personally just had tummy troubles for a few days.” In context ↗ Gut side effects
Symptoms mentioned
Their words about their symptoms
- Pain & fibromyalgia
I had chronic muscle pain prior to infection because of the underlying heds
In context ↗ - Post-exertional malaise
Continued to push through, what I now know to be, rolling PEM.
In context ↗ - Brain fog
I still get it, but mostly from pots (which is currently unmedicated) and no where near as bad.
In context ↗ - POTS & dysautonomia
I also have diagnosed pots.
In context ↗ - Mast cell (MCAS) & allergies
ketotefin for mcas
In context ↗ - Headaches & migraine
to manage cognitively fatigue and prevent headaches
In context ↗ - Muscle weakness
now also muscles that fatigued with little exersion
In context ↗
Ask Miruvor AI
Similar stories
-
Bedbound with severe ME/CFS, now moving toward moderate with pacing and LDN
Ill with ME/CFS since a viral infection at age 8 in 2012, they fluctuated between mild and moderate/severe for over a decade. A virus in early 2025 dropped them from near remission to severe and bedbound, with worse POTS and suspected MCAS. Low-dose…
-
Not enough detail to draw a path
Mostly housebound with ME/CFS, now much better with low-dose naltrexone and Abilify
They fell ill with ME/CFS after a mono infection, were mild at first, then crashed to mostly housebound after pushing through college. Low-dose naltrexone, low-dose Abilify and oxaloacetate improved them substantially over the past five years, alongside…
-
Bedbound with long COVID, now much better with LDN and a low-histamine diet
After a COVID infection in March 2022 they declined over 17 months from part-time chef work to fully bedbound from August 2023. LDN, ivabradine, low-histamine diet, physio and nervous-system/mind-body work brought slow gains, helped by moving in June 2024 to…
-
Couch-bound for months with long COVID, now much better after pacing and IVIG
A fitness instructor in her forties, she fell ill with COVID in March 2020 and was couch-bound for months with POTS, MCAS, small fibre neuropathy and ME/CFS. She credited pacing, IVIG, POTS medication and BPC-157 for a slow climb to about 85% of her former…