Long COVID crash left them barely able to hold a toothbrush; DAO enzymes helped somewhat
- Condition
- Long COVID
- At worst
- Severe (mostly bedbound)
- Ill before improving or writing
- Not stated
- Last post
- Oct 2026
In their words
- Condition: Long COVID
POTS/MCAS/LONG C/Dysautonomia suspected EDS here and would love any insight.
In context ↗ - At worst: Severe
eventually I could barely swallow, couldn’t get off the sofa, severe memory issues, concept of time screwed up
In context ↗ - Now: Somewhat better
Now I can’t put all my dishes away in one shot, I have to do it in stages.
In context ↗
Read from 8 of their posts and comments; links to the 8 this page draws on
Summary
Mesa 98072 has long COVID with POTS, MCAS, brain fog and arm weakness, having been a daily gym-goer before. A progesterone reaction and its withdrawal caused a major crash, barely able to hold a toothbrush or leave the sofa; a week of ER prednisone briefly helped, then stopping it destroyed them. Building dust, fumes and moisture damage triggered severe reactivity and most supplements caused agitation. DAO enzymes helped, but they still do chores in stages.
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What they tried
What they credit
Also tried
Their words about each treatment
- DAO enzymes · Helped
DAO enzymes have helped me a lot too.
In context ↗ - B vitamins (B1, B2, B9) · Worse
tried micro-dosing B1, B2 & B9 and no bueno
In context ↗ - CoQ10 · Worse
Tried CoQ10, ALA, Quercetin even DIM for the estrogen (COMT) and had a horrible wired/agitated reaction to each of them.
In context ↗ - Quercetin · Worse
Quercetin causes severe agitation as does B12
In context ↗ - DIM · Worse
even DIM for the estrogen (COMT) and had a horrible wired/agitated reaction to each of them
In context ↗ - Mag Glycinate & Threonate · Worse
Mag Glycinate & Threonate left me comatose.
In context ↗ - Urolithin-A · Not said
The only thing I can handle is Urolithn-A at 1/8 dose, l-theanine and Taurine.
In context ↗ - Impulse app and other cognitive training apps · No change
Downloaded quite a few and only continued to use impulse app for when I was overwhelmed.. Nothing for cognitive improvement stuck with me.
In context ↗ - Guava app, Visible app, Elite HRV app, Polar strap · Not said
I’ve used Guava app to record symptoms/supplements etc..
In context ↗ - progesterone · Much worse
progesterone in every form destroyed me but microionised was the worst - even at low dose 100mg & non orally
In context ↗ - prednisone · Helped
while on them I felt amazing ... coming off that week of steroids destroyed me
In context ↗ - probiotics and fermented foods · Worse
even probiotics - any fermented food including my stupid $5 dairy free low sugar organic yogurts.. are major NO for me now too
In context ↗ - testosterone · Worse
starting testosterone may have added to my issues too
In context ↗ - aspirin · Helped
I ultimately didn’t take Montelukast as the aspirin worked
In context ↗
Approaches: Anticoagulants · Antihistamines & MCAS
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. 5 steps say too little to place on the scale and are only in the table. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| — | long COVID with POTS, MCAS and dysautonomiaPOTS/MCAS/LONG C/Dysautonomia suspected EDS hereIn context ↗ | Not stated | |
| — | major crash from progesterone and its withdrawaleventually I could barely swallow, couldn’t get off the sofa, severe memory issues, concept of time screwed upIn context ↗ | Severe | |
| — | felt amazing while on a week of prednisone from the ERwhile on them I felt amazing ... It was like my brain network came back online with the prednisone clearing the inflammationIn context ↗ | Not stated | Corticosteroid pulses |
| — | crashed after stopping the week of prednisoneBUT coming off that week of steroids destroyed meIn context ↗ | Not stated | |
| — | mould exposure from building work and water leaks triggered hyperreactivityBuilding construction/fumes/dust & repeat water leaks/moisture damage then sent my body into total hyperactive state where I reacted to EVERYTHING!In context ↗ | Not stated | |
| 2026-01-10 | DAO enzymes helpedDAO enzymes have helped me a lot too.In context ↗ | Not stated | DAO enzymes |
| 2026-09-05 | still limited, chores done in stages, weak arms and handsNow I can’t put all my dishes away in one shot, I have to do it in stages.In context ↗ | Moderate |
Adverse events
- Vitamin B12“Quercetin causes severe agitation as does B12” In context ↗ Side effects
- “I can’t handle B vitamins especially methylated, tried micro-dosing B1, B2 & B9 and no bueno.” In context ↗ Side effects
- CoQ10 / ubiquinol“Tried CoQ10, ALA, Quercetin even DIM for the estrogen (COMT) and had a horrible wired/agitated reaction to each of them.” In context ↗ Side effects
- Alpha-lipoic acid (ALA, R-ALA)“Tried CoQ10, ALA, Quercetin even DIM for the estrogen (COMT) and had a horrible wired/agitated reaction to each of them.” In context ↗ Side effects
- Baicalein and quercetin“Quercetin causes severe agitation as does B12” In context ↗ Side effects
- DIM (diindolylmethane)“Tried CoQ10, ALA, Quercetin even DIM for the estrogen (COMT) and had a horrible wired/agitated reaction to each of them.” In context ↗ Side effects
- Magnesium“Mag Glycinate & Threonate left me comatose.” In context ↗ Side effects
- Progesterone (Prometrium, Utrogestan)“progesterone in every form destroyed me but microionised was the worst ... Left me like a rubber woman, could barely hold a toothbrush” In context ↗ Side effects
- Progesterone (Prometrium, Utrogestan)“an even worse Withdrawl from it - god awful, that caused a major crash, POTS/neuromuscular issues and 10year+ Bell’s palsy paralysis on my face became worse for 1st time ever” In context ↗ Withdrawal problems
- Progesterone (Prometrium, Utrogestan)“10year+ Bell’s palsy paralysis on my face became worse for 1st time ever -> ER visit” In context ↗ ER visit
- Corticosteroid pulses“BUT coming off that week of steroids destroyed me. Destroyed me!” In context ↗ Withdrawal problems
- Probiotics and fermented foods“even probiotics - any fermented food including my stupid $5 dairy free low sugar organic yogurts.. are major NO for me now too.” In context ↗ Made symptoms worse
- Testosterone“starting testosterone may have added to my issues too.. hr is all over the place and vasospasm like contractions in chest, neck,, back of head.” In context ↗ Side effects
- Aspirin“some days it makes symptoms worse” In context ↗ Made symptoms worse
Symptoms mentioned
Their words about their symptoms
- POTS & dysautonomia
POTS/MCAS/LONG C/Dysautonomia suspected EDS here
In context ↗ - Mast cell (MCAS) & allergies
sent my body into total hyperactive state where I reacted to EVERYTHING!
In context ↗ - Brain fog
brain fog so bad I couldn’t follow the steps To make a sandwich
In context ↗ - Muscle weakness
Add in weak arms, losing function of hands due to cervical compressions
In context ↗ - Neuropathy & tingling
can’t even raise arms without getting burning/tingling and blurred vision
In context ↗
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