Barely able to get out of bed with long COVID, now nearly back to normal after Alpha GPC
- Condition
- Long COVID
- At worst
- Severe (mostly bedbound)
- Ill before improving or writing
- 6 years
- Last post
- Mar 2026
In their words
- Condition: Long COVID
my extreme long covid fatigue and brainfog
In context ↗ - At worst: Severe
extreme mental and physical fatigue where I have a very hard time participating in a conversation or even just getting out of bed
In context ↗ - Now: Near normal
I still have rough phases here and there ... but other than that I mostly have good days.
In context ↗ - Began after: COVID
Was very sick with flu-like symptoms early last year, possibly COVID19.
Read from 14 of their posts and comments; links to the 9 this page draws on
Summary
Island 60572, a 37-year-old man, fell ill in early 2020 with a flu-like illness, probably COVID-19, followed by extreme physical and mental fatigue and brain fog that left him barely able to get out of bed. High-dose Alpha GPC, later d-ribose with creatine, and finally pregnenolone lifted him to mostly good days, though benefits faded or needed to be maintained. He remained dependent on his supplements.
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What they tried
What they credit
Also tried
Their words about each treatment
- Alpha GPC · Helped a lot
High dose (1g) of Alpha GPC or 200mcg Huperzine A reliably completely eliminates my extreme physical and mental chronic fatigue
In context ↗ - COVID vaccine · Worse
The first shot of the vaccine completely eliminated all symptoms for almost 2 weeks.
In context ↗ - ResveraCel (Thorne's Nicotinamide Riboside + Resveratrol formula) · Helped
ResveraCel (Thorne's Nicotinamide Riboside + Resveratrol formula) ... Parts of my stack that seem to synergize with this as I notice the effects seem even better with these.
In context ↗ - Phosphatidylserine · Helped
Phosphatidylserine ... Parts of my stack that seem to synergize with this as I notice the effects seem even better with these.
In context ↗ - Methyl-Guard Plus (Thorne's methylated B-vitamin complex) · Helped
Methyl-Guard Plus (Thorne's methylated B-vitamin complex) ... Parts of my stack that seem to synergize with this as I notice the effects seem even better with these.
In context ↗ - Agmatine sulfate · Helped
Agmatine sulfate ... Parts of my stack that seem to synergize with this as I notice the effects seem even better with these.
In context ↗ - l-carnitine complex · Helped
An l-carnitine complex that contains acetyl-l-carnitine/fumarate/tartrate ... Parts of my stack that seem to synergize with this as I notice the effects seem even better with these.
In context ↗ - yerba mate · Helped
A few cups of yerba mate also helps since it contains so many energy/mood-lifting components
In context ↗ - CDP choline/citicoline · Not said
I've tried CDP choline/citicoline and I get the impression the alpha gpc is more potent.
In context ↗ - choline bitartrate · Not said
I have also tried bitartrate but not extensively enough yet to tell if that does much.
In context ↗ - emoxypine · Helped a lot
one of the supplements that have helped by far the most is emoxypine
In context ↗ - d-ribose · Helped a lot
I'm currently having around 10-15g of d-ribose and 10g of creatine with my breakfast.
In context ↗ - creatine · Helped a lot
upping my daily intake of creatine from 5g to 10-20g
In context ↗ - pregnenolone · Helped a lot
adding pregnenolone to this stack is a massive help, has become the core component of my stack along with the d-ribose.
In context ↗ - DHEA · Helped
50mg of pregnenolone or DHEA in the morning (DHEA on rougher days)
In context ↗
Approaches: Amino acids and carnitine · Hormones & thyroid · Other drugs and medicines · Supplements
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| early 2020 | flu-like illness followed by extreme physical and mental fatigueQuickly developed extreme chronic physical and mental fatigue afterwards that has not gone away.In context ↗ | Severe | |
| mid 2021 | first vaccine shot cleared all symptoms for nearly two weeksThe first shot of the vaccine completely eliminated all symptoms for almost 2 weeks.In context ↗ | Near normal | COVID vaccination as treatment |
| July 2021 | high-dose Alpha GPC gave normal energy within an hourwithin the hour, had normal energy levels, no brainfog, overall great mood and full cognitive abilitiesIn context ↗ | Mild | |
| 2021-08-06 | crashed after second vaccine shotI got my second vaccine shot a bit over a week ago and ever since then I've been a complete wreck again.In context ↗ | Severe | |
| 2022-10-26 | d-ribose and creatine made most of the day feel normalIt's really impressive how this combination has me feeling pretty 'normal' for most of the dayIn context ↗ | Mild | Creatine |
| 2025-01-07 | pregnenolone added to the stack, massive helpadding pregnenolone to this stack is a massive help, has become the core component of my stack along with the d-riboseIn context ↗ | Mild | |
| 2026-03-25 | mostly good days, still needs an hour or two each morningI still have rough phases here and there and I tend to need an hour or two after waking up in the morning before my brain and body are functioning properly, but other than that I mostly have good days.In context ↗ | Near normal |
Adverse events
- COVID vaccination as treatment“I got my second vaccine shot a bit over a week ago and ever since then I've been a complete wreck again.” In context ↗ Made symptoms worse
- D-ribose“I also experienced heavy dizziness, palpitations and fatigue first time I took d-ribose.” In context ↗ Side effects
- Creatine“I do cycle the creatine because some people, me included, are sensitive in a way where it degrades your sleep quality when taking too much for too long.” In context ↗ Insomnia from treatment
Symptoms mentioned
Their words about their symptoms
- Brain fog
it also helped significantly with brainfog but overall there still remained quite a high degree of mental fatigue and brainfog
In context ↗ - Anxiety & low mood
Anxiety has rarely been an issue in my long covid journey although I have had phases where I did have it to an extreme degree.
In context ↗
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