Long COVID
Severe → much betterIll 14 months before improving or writingNeeds ongoing treatment
Housebound with long COVID, now much better after SS-31 and meditation
- Condition
- Long COVID
- At worst
- Severe (mostly bedbound)
- Ill before improving or writing
- 14 months
- Last post
- Aug 2025
In their words
- Condition: Long COVID
I’ve had long covid since November of 2023.
In context ↗ - At worst: Severe
At my worst I literally could do nothing but lie on the floor and pant.
In context ↗ - Now: Much better
Personally I have gone from severe to mild by addressing mitochondrial dysfunction and chronic inflammation.
In context ↗ - Began after: COVID
woke up sick with covid the next day
- Says they never had: Mast cell (MCAS) & allergies
I don’t have MCAS
Read from 100 of their posts and comments; links to the 41 this page draws on
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Summary
Lagoon 55763 developed long COVID in November 2023 after a COVID infection following a 40 km mountain hike, and in July 2024 was housebound, lying on the floor all day. From December 2024 they built a mitochondrial protocol centred on the peptide SS-31, supplements and daily meditation, going from severe to mild-moderate and able to lift weights and walk miles, though still limited, not fully recovered and still having bad days and PEM. SS-31 cost $150 a vial.
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What they tried
What they credit
SS-31· Helped a lot · mainNADH (sublingual powder / ENADA lozenges)· HelpedPQQ· HelpedNMN· HelpedOptinad· Helpedmeditation (Waking Up app)· HelpedD-ribose· Helpedcreatine· HelpedALCAR· Helpedubiquinol· HelpedEGCG· Helpedtrans-resveratrol· Helpedomega 3· Helpedtaurine· Helpedpacing (hard limits on activity)· Helpedmolecular hydrogen water· Helpedtherapy· Helped
Also tried
essential oil smell training· Helped a lotcannabis (THC/CBD)· HelpedLDN· Helpedcold showers and ice packs· Helpedjournaling· Helpedtropisetron· Helpedcurcumin (curcuminoids) with piperine· HelpedSAM-e/betaine· Helpedmodafinil· HelpedProdromeGlia plasmalogens· HelpedL-ergothioneine· Helpedcarnosic acid· Helpedlithium ascorbate· Helpedintranasal SkQ1· Helpedhydration and sodium· HelpedNAC· No changebupropion· No changeNSAIDs· No changeH1 antihistamines (fexofenadine)· No changefamotidine· No changetetramethoxyluteolin (Experikenra)· No changemethylene blue· No changel-arginine, citrulline and vitamin C· No changeshrooms (psychedelics)· Worsefasting· WorseIntermittent fasting· Worseoxaloacetate· Not saidapigenin· Not said
Their words about each treatment
- essential oil smell training · Helped a lot
Within a few days I could just barely start to smell them, and this gave me the encouragement to keep doing it till everything went back to normal. ... In the end I recovered my sense of smell much more rapidly than anyone else I knew (about 9 days).
In context ↗ - cannabis (THC/CBD) · Helped
Cannabis is amazing for rapid recovery from symptoms.
In context ↗ - shrooms (psychedelics) · Worse
Ever since I got LC shrooms make me feel TERRIBLE.
In context ↗ - NAC · No change
I have never noticed NAC do anything except make hangovers almost non-existent
In context ↗ - NADH (sublingual powder / ENADA lozenges) · Helped
sublingual NADH definitely helps me
In context ↗ - PQQ · Helped
I believe PQQ also helps, though less noticeably than sublingual NAD.
In context ↗ - NMN · Helped
SS-31, NMN, PQQ, ALCAR, D-Ribose, ubiquinol, egcg, curcuminoids + piperine, SAM-e/betaine, omega 3, LDN.
In context ↗ - Optinad · Helped
Optinad is oral and works very noticeably but it made me very irritable for some reason and it’s kind of expensive.
In context ↗ - LDN · Helped
anecdotally that LDN appears to be helping me with fatigue
In context ↗ - cold showers and ice packs · Helped
Alternating hot and cold showers make me feel better, as well as ice pack on the upper chest/back of neck.
In context ↗ - journaling · Helped
Meditation and journaling for psychological relief.
In context ↗ - meditation (Waking Up app) · Helped
The catalyst for those psychological changes was meditation every single day using the Waking Up app.
In context ↗ - tropisetron · Helped
Every time I’ve dosed it, I’ve noticed a modest yet rapid relief of inflammation and brain fog.
In context ↗ - bupropion · No change
Bupropion doesn’t do much for dopamine, speaking personally and based on some evidence.
In context ↗ - NSAIDs · No change
the relief is far more pronounced than anything I’ve gotten from NSAIDs
In context ↗ - H1 antihistamines (fexofenadine) · No change
I went all the way and sourced experikenra tetramethoxyluteolin (possibly the most potent mast cell inhibitor in existence) and none of these did anything for me.
In context ↗ - fasting · Worse
to be honest fasting just makes me feel worse
In context ↗ - oxaloacetate · Not said
I am also experimenting with oxaloacetate and apigenin.
In context ↗ - SS-31 · Helped a lot
For almost the entire 100 days I did 2 mg per day. It really helped a lot and I’ve gained ground
In context ↗ - D-ribose · Helped
I’m actually new to D ribose but definitely feel a difference.
In context ↗ - creatine · Helped
creatine 5 g per day - facilitates ATP production
In context ↗ - ALCAR · Helped
I’ve always found taurine, pqq and alcar helpful and I continue to take them.
In context ↗ - EGCG · Helped
I believe they did help because they’ve been demonstrated in research to directly inhibit IDO/TDO
In context ↗ - curcumin (curcuminoids) with piperine · Helped
I also take curcumin extract w/ piperine, egcg and trans-resveratrol to attenuate the IDO/TDO pathway
In context ↗ - trans-resveratrol · Helped
egcg, curcuminoids, trans-resveratrol <- these 3 directly downregulate the inflammatory IDO/TDO chronix upregulation seen in post-viral fatigue but they must be taken with piperine for absorption.
In context ↗ - taurine · Helped
Taurine has a slight calming effect and helps balance the jitteriness of caffeine.
In context ↗ - pacing (hard limits on activity) · Helped
Behavioral changes - Setting hard limits on my activities.
In context ↗ - modafinil · Helped
I really like 100 mg and only use 200 on days when I need to lock in and hyperfocus.
In context ↗ - methylene blue · No change
I personally was never impressed with it on its own
In context ↗ - ProdromeGlia plasmalogens · Helped
I think it helped a little.. maybe? It’s just way, way too expensive for the marginal benefit.
In context ↗ - L-ergothioneine · Helped
Nowadays I’m using L-ergothioneine, carnosic acid, lithium ascorbate, and intranasal skq1. ... feels cleaner and more effective than using polyphenols
In context ↗ - molecular hydrogen water · Helped
It helps me avoid getting cooked by PEM
In context ↗ - l-arginine, citrulline and vitamin C · No change
Citrulline, l-arginine and vitamin c are useful supplements, but they did not help me recover
In context ↗ - hydration and sodium · Helped
Lots of hydration and sodium help.
In context ↗ - therapy · Helped
purposefully destressing through disciplined meditation practice and therapy
In context ↗ - Intermittent fasting · Worse
Yeah to be honest fasting just makes me feel worse.
In context ↗
Approaches: CBT & mindset · Amino acids and carnitine · Mind-body practices · Pacing · Peptides · Supplements
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| November 2023 | long covid began after a 40 km mountain hike and a covid infectionIt started after I did a 40 kilometer hike up one of the tallest mountains in Ukraine and woke up sick with covid the next day.In context ↗ | Mild | |
| June 2024 | briefly felt recovered, no symptoms on a long road tripBy June I thought I was basically cured.In context ↗ | Near normal | |
| July 2024 | crash to a lower baseline, likely reinfection; lying on the floor all dayin July my LC came back with an absolute vengeance ... I would wake up, lie down on the meditation mat on my floor and stay there until night.In context ↗ | Severe | |
| November 2024 | started getting somewhat functional againIt wasn’t until November I started getting somewhat functional again, though I still had fatigue, severe brain burning and emotional disturbances every day.In context ↗ | Moderate | |
| January 2025 | mitochondrial protocol began to show resultsI basically just plateau’d until early January when my protocol (which I started in December) started to show results.In context ↗ | Moderate | SS-31 (elamipretide) |
| February 2025 | got through a 5-hour political demonstration without crashingToday I was at a 5 hour physically intensive political demonstration for Ukraine and have not crashed (though I am quite tired).In context ↗ | Moderate | SS-31 (elamipretide) |
| March 2025 | lifting weights and taking multi-mile walks 2-3 times a weekI went from not even being able to walk down the street without my heart pounding and my brain burning, to lifting weights and taking multi-mile walks 2-3 times a week.In context ↗ | Mild | SS-31 (elamipretide) |
| April 2025 | a bit of a relapseI too have had a bit of a relapse recently and while it’s demoralizing, it also means your progress was real.In context ↗ | Mild | |
| August 2025 | still mild, not fully recovered, milder PEMI have gone from severe to mild by addressing mitochondrial dysfunction and chronic inflammation.In context ↗ | Mild |
Adverse events
- “The only side effect is constipation, so not a big deal.” In context ↗ Gut side effects
- NAD+ boosters (NMN, nicotinamide riboside, NADH, ATP)“Optinad is oral and works very noticeably but it made me very irritable for some reason” In context ↗ Mood or psychiatric effects
- Intermittent fasting“Yeah to be honest fasting just makes me feel worse.” In context ↗ Made symptoms worse
- Modafinil / armodafinil“Then that rubber band comes snapping all the way back and you feel worse than you would have if you hadn’t taken moda and overexerted yourself.” In context ↗ Made symptoms worse
- Modafinil / armodafinil“I didn’t get any energy just a kind of inebriated feeling.” In context ↗ Side effects
- SS-31 (elamipretide)“The first time I did 3 mg early on it made me feel strange.” In context ↗ Side effects
Symptoms mentioned
Anxiety & low moodBrain fogHeadaches & migraineHeart symptoms & palpitationsLoss of smell or tastePost-exertional malaiseTemperature regulation
Their words about their symptoms
- Post-exertional malaise
Even on my good days I get a little PEM and brain burning
In context ↗ - Brain fog
Fatigue, brain fog, brain burning from severe down to mild-moderate
In context ↗ - Headaches & migraine
These include brain fog, fatigue, headaches abd pressure, inflammation and pain in the sinus and intracranial tissues.
In context ↗ - Heart symptoms & palpitations
not even being able to walk down the street without my heart pounding and my brain burning
In context ↗ - Anxiety & low mood
I just start to contemplate suicide.
In context ↗ - Temperature regulation
heat most definitely worsens my symptoms
In context ↗ - Loss of smell or taste
anosmia was practically my only symptom
In context ↗
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