Long COVID with neurological symptoms, now nearly back to normal after low-dose naltrexone
- Condition
- Long COVID
- At worst
- Severe (mostly bedbound)
- Ill before improving or writing
- 18 months
- Last post
- Oct 2026
In their words
- Condition: Long COVID
still came down with LC about 6 months after infection in late 2022 (Omicron)
In context ↗ - At worst: Severe
Went from 20 to 90 within weeks.
In context ↗ - Now: Near normal
Got better about 1 1/2 years ago except for some numbness (small fiber neuropathy) to bottom of feet ... I'm back to 95% of former self.
- Began after: COVID
still came down with LC about 6 months after infection in late 2022 (Omicron)
In context ↗
Read from 35 of their posts and comments; links to the 15 this page draws on
Summary
A Reddit user developed long COVID about six months after a COVID infection in late 2022, then spent roughly 1–1.5 years with PEM, poor sleep, itchy skin, aching hands, malaise and neurological symptoms. Low-dose naltrexone and methylene blue, started in 2024, helped within weeks, and Allegra plus famotidine controlled histamine flares. By October 2026 they reported being back to about 95% of their former self, having earlier noted numb feet.
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What they tried
What they credit
Also tried
Their words about each treatment
- LDN (low dose naltrexone) · Helped a lot
90% better after 3 months. Noticed a difference within first week.
In context ↗ - Methylene Blue · Helped a lot
Post COVID it helped clear my brain fog dramatically almost overnight.
In context ↗ - Allegra (H1 antihistamine) · Helped
the antihistamines took care of the itchy skin/achy hands
In context ↗ - Pepcid (famotidine) · Helped
an H1 (Allegra 180mg) at night before bed, and then an H2 (Pepcid 20mg) in the morning
In context ↗ - maraviroc · No change
I tried this protocol for 4 months with Dr Patterson. Didn’t solve my issues… primarily PEM
In context ↗ - dextromethorphan · Helped
LDN, methylene blue, dextromethorphan… worked for my neuro issues, new autoimmune issues, and PEM.
In context ↗ - hydrocortisone 1% · Helped
Over the counter hydrocortisone 1%, twice a day for a few days worked for me.
In context ↗ - ePothex povidone/iodine nasal spray · Not said
Caught covid once in Sept 22’ and haven’t gotten it again since I started this practice.
In context ↗
Approaches: H1 antihistamines · H2 blockers · Other drugs and medicines
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. The chart starts 12 months after onset: the story doesn’t say how ill they were before that. 1 step says too little to place on the scale and is only in the table. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| 2023 (about 6 months after the COVID infection) | long COVID began about six months after a COVID infection in late 2022still came down with LC about 6 months after infection in late 2022 (Omicron)In context ↗ | Not stated | |
| 2024 | a mess all of 2024: PEM, poor sleep, itchy skin, aching hands, malaise, dissociation and apathyI was a mess all of 2024.In context ↗ | Severe | |
| mid-2024, within weeks of starting | started LDN and methylene blue and improved within weeksWent from 20 to 90 within weeks.In context ↗ | Near normal | Low-dose naltrexone |
| October 2026 | back to 95% of former self, with numb feet and occasional histamine flares remainingI’m back to 95% of former self.In context ↗ | Near normal |
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
PEM, poor sleep, itchy skin, aching hands, periodic general malaise
In context ↗ - Mast cell (MCAS) & allergies
occasional histamine flares controlled by H1 and H2 antihistamines
In context ↗ - Headaches & migraine
joint aches, headaches, fatigue, feeling unwell generally
In context ↗ - Brain fog
it helped clear my brain fog dramatically almost overnight
In context ↗ - Neuropathy & tingling
some numbness (small fiber neuropathy) to bottom of feet
In context ↗ - Flu-like symptoms
periodic general malaise
In context ↗ - Anxiety & low mood
cured my anhedonia in days
In context ↗ - Vision problems
Increased ocular pressure for couple years. Back to normal.
In context ↗
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