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Long COVID Mild → no benefitIll for 4.5 yearsNeeds ongoing treatment

Long COVID breathlessness, no improvement after supplements and hyperbaric oxygen

Condition
Long COVID
At worst
Mild (working or studying, with limits)
Ill for
4.5 years
Last post
Sep 2026
In their words
  • Condition: Long COVIDcaught omicron Dec ‘21, long hauling ever since In context ↗
  • At worst: MildI have worked straight through all of this ... at a greatly reduced productive capacity In context ↗
  • Now: No benefitjust my symptoms never resolved In context ↗
  • Began after: COVIDcaught omicron Dec ‘21, long hauling ever since In context ↗
Read from 69 of their posts and comments; links to the 42 this page draws on

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Summary

A Texas veterinarian caught COVID in December 2021 and has had long COVID since, with breathlessness, chest pain, insomnia and post-exertional malaise. A third Moderna booster in mid-2022 caused a major setback she never fully recovered from. She kept working at reduced capacity while trying supplements, hyperbaric oxygen, low-dose naltrexone and fasting, with only small gains such as better sleep and higher resting oxygen.

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What they tried

Their words about each treatment
  • Sleepzyme (melatonin-based supplement) · No changeI’ve been taking a melatonin-based supplement (Sleepzyme) which has various herbal compounds, but it leaves me groggy and STILL not feeling well rested. In context ↗
  • Trazodone · WorseA therapist years ago Rx’d Trazodone which left me with even worse “hangover” symptoms; it just wasn’t worth it to me! In context ↗
  • Wellbutrin · WorseI had to give it up after about a week of low-grade GI misery and a strange incipient headache In context ↗
  • Lexapro · Worseover past decades of struggles against chronic depression & anxiety, I’ve tried several but found side effects intolerable: Wellbutrin, Lexapro, Trazodone, Zoloft In context ↗
  • Acupuncture · Not saidI started acupuncture treatments three weeks ago - he shows me pretty colored bars on graphs which are changing; it also seems to have triggered some night sweats but hard to say if it is helping to any great extent at this point? In context ↗
  • Hot yoga / low-intensity yoga · HelpedEven then there’s a price to be paid with minor “crash” the day after, but it’s worth it as much for my mental health as the physical benefits. In context ↗
  • Famotidine · WorseFamotidine doesn’t seem to help my brain fog - in fact it seems to exacerbate it. In context ↗
  • Sertraline · HelpedI’ve been taking low-dose sertraline these past couple of weeks which seems to be helping with my sleep In context ↗
  • Ibuprofen · HelpedSo far it does seem to be responding to ibuprofen, thank goodness. In context ↗
  • Chinese herbs (Long Haul Tea) · No changeYep I drank it for a good solid month - it certainly didn’t hurt anything except my taste buds, but I can’t really say it did me any good? In context ↗
  • B-complex · HelpedI have been on my “enhanced supplement protocol” which includes B-complex, black seed oil, quercetin, CoQ10, etc for several months & while it may be helpful, it hasn’t been phenomenally so. In context ↗
  • Black seed oil · Helpedas I empty out these bottles, the only ones I will replace is the nattokinase and blackseed oil In context ↗
  • Quercetin · Not saidRight now I’m taking only magnesium, blackseed oil, & quercetin, when I finish off the quercetin I’ll probably discontinue it as well. In context ↗
  • Colchicine · Not saidI started taking colchicine last week; too soon to tell if it is helping much (yet)? In context ↗
  • Moderna third booster · Much worseI let my new doctor talk me into a third Moderna booster last week - it has caused a major setback with worsening shortness of breath/heart palpitations In context ↗
  • Low-dose naltrexone · Helpedthis micro dose does seem to help my sleep quite a bit. In context ↗
  • Magnesium · Not saidMagnesium is primarily for sleep (ha ha) In context ↗
  • CBD · HelpedI have been taking some CBD which seems to help In context ↗
  • Melatonin · Not saidFor sleep I am taking magnesium, CBD, low-dose melatonin In context ↗
  • Yoga nidra · HelpedYoga nidra FTW! I listen to a short session every night - it helps me fall asleep. In context ↗
  • Yogic breathing exercises · Not saidI have been taking some CBD which seems to help and practicing yogic breathing exercises In context ↗
  • Herbal powders · Not saidseveral herbal powders recommended by an Eastern-medicine guru whom I follow In context ↗
  • Cetirizine · WorseMost antihistamines knock me on my ass, cetirizine was no exception although it didn't hit me "quite" as hard as other antihistamines. In context ↗
  • Aspirin · HelpedI took nattokinase for months with no real improvement, so I’ve gone back to low-dose aspirin which does seem to help In context ↗
  • ImmunoShot (glutathione, vitamin C, zinc injection) · WorseThese vitamin infusions may work great for some folks, but my system did not appreciate at all! In context ↗
  • Tramadol · Not saidtook a Tramadol when I got home In context ↗
  • Tylenol · Not saidI’ve taken my ibuprofen & Tylenol In context ↗
  • Probiotics · Not saidSome GI distress with bloat (4 lbs overnight, really??) for which I took some probiotics. In context ↗
  • Lithium orotate · Much worseLithium orotate even at micro dose levels (2.5 mg, 1/4 tablet) knocked me on my butt. In context ↗
  • Spike Protein supplement (natto & herbal compounds) · WorseI have felt worse since starting a new “Spike Protein” supplement (it has natto & several other herbal compounds) In context ↗
  • Nattokinase · No changeI took nattokinase for months with no real improvement In context ↗
  • Cymbalta · WorseTwo months ago she talked me into trying Cymbalta - I took it for about two weeks and then I set it aside, the low-grade GI misery just wasn’t worth it. In context ↗
  • Cannabis gummy · Helpedfor anxiety relief I will take a fractionated gummy on occasion - the problem is THC makes me very lazy! In context ↗
  • Thiamine · Not saidthe plentiful rack o’ supplements (natto, BSO, thiamine, bibbity bobbity boo with Chinese herbs recommended by another long hauler which didn’t help much) In context ↗
  • Dandelion root capsules · Not saidCurrently taking quercetin, CoQ10, BSO, & dandelion root capsules. In context ↗
  • Radical rest · HelpedI also cannot retire & have managed to “keep on keeping on” by radically resting, marshaling my limited energy reserves to struggle through each workday. In context ↗
  • Hyperbaric oxygen (HBOT) · Helpedmain benefit I have noticed is gradual increase in my resting pO2, which has crept up from 93 to 97%. In context ↗
  • Intermittent fasting / OMAD · HelpedBut I DO feel better overall if I stick to an OMAD routine In context ↗
  • Oral thyroid replacement · Not saidI have been thyroidectomized so 100% reliant on oral thyroid replacement In context ↗
  • Artificial tear solution · Not saidI use artificial tear solution, but sometimes I wake up in considerable discomfort In context ↗

Their path

Very severeSevereModerateMildNear normalRecovered12 mo2 y3 y4 y

How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. The chart starts 3 months after onset: the story doesn’t say how ill they were before that. 1 step says too little to place on the scale and is only in the table. Dates are when they posted. What the levels mean.

Show as a table
WhenWhat happenedWhere they wereAfter
December 2021COVID infection (omicron)caught omicron Dec ‘21, long hauling ever since In context ↗Not stated
March 2022slow improvement over first monthsI do seem to be slowly improving (a little over 3 mos out) In context ↗Mild
May 2022relapse after overdoing it on Mother's Day weekendwhen I have a good day & try to do too much, invariably I will relapse and put myself back in the ditch. (such was the case after Mother’s Day weekend) In context ↗Mild
June 2022crashed after third Moderna boosterI let my new doctor talk me into a third Moderna booster last week - it has caused a major setback with worsening shortness of breath/heart palpitations In context ↗Mild
September 2022slow gains, managing low-intensity yogaI’m 9 mos in, the best I can manage these days are low-intensity yoga classes. Even then there’s a price to be paid with minor “crash” the day after In context ↗Mild
October 2022severe relapse after judging an equestrian event on her feet all dayjudged an equestrian event Saturday which required me to be up early & stay on my feet most of the day, so now I am suffering a severe relapse In context ↗Mild
December 2023resting oxygen levels crept up with hyperbaric oxygenmy pO2 reads 97 which is the highest it’s been in months (used to hang around 92-3, but has crept up point by point since I started hyperbaric oxygen treatments these past 6 wks In context ↗MildHyperbaric oxygen (HBOT)
January 2024still limited going into year threeHeading into Year 3 & this may be as good as it gets? In context ↗Mild
April 2025felt better overall on one meal a dayBut I DO feel better overall if I stick to an OMAD routine In context ↗MildIntermittent fasting
September 2026still long hauling, intermittent fasting helpfulI have done intermittent fasting, which seems to be helpful In context ↗MildIntermittent fasting

Adverse events

  • “I’ve been taking a melatonin-based supplement (Sleepzyme) which has various herbal compounds, but it leaves me groggy and STILL not feeling well rested.” In context ↗ Side effects
  • Trazodone (Desyrel)“A therapist years ago Rx’d Trazodone which left me with even worse “hangover” symptoms; it just wasn’t worth it to me!” In context ↗ Side effects
  • Trazodone (Desyrel)“new MD is trying to be helpful but so far trazodone leaves me even more flatline depressed & I refuse to take an SSRI” In context ↗ Mood or psychiatric effects
  • Acupuncture“it also seems to have triggered some night sweats but hard to say if it is helping to any great extent at this point?” In context ↗ Side effects
  • COVID vaccination as treatment“it has caused a major setback with worsening shortness of breath/heart palpitations, muscular soreness, low-grade headache and just generally feeling like crap.” In context ↗ Made symptoms worse
  • Famotidine (Pepcid)“Famotidine doesn’t seem to help my brain fog - in fact it seems to exacerbate it.” In context ↗ Made symptoms worse
  • Sertraline (Zoloft)“the half-doses of sertraline I took as a sleep aid likewise left me feeling worse instead of better.” In context ↗ Side effects
  • Chinese herbal medicine (TCM formulas)“It kinda hit my GI tract like a depth charge ... luckily only moderate cramping, bloat & gas.” In context ↗ Gut side effects
  • Low-dose naltrexone“I took 1.5 mg twice last weekend, then I couldn’t understand why I was so zombified? I was extremely drowsy, seemed as if I could never “wake up” even with extra caffeine.” In context ↗ Side effects
  • Bupropion (Wellbutrin)“it didn’t sit well with me - I had to give it up after about a week of low-grade GI misery and a strange incipient headache” In context ↗ Side effects
  • Cetirizine (Zyrtec)“Most antihistamines knock me on my ass, cetirizine was no exception although it didn't hit me "quite" as hard as other antihistamines.” In context ↗ Side effects
  • IV vitamins and Myers cocktail“this morning I am really stiff & sore, with a flare-up of generalized joint pain and lethargy, all I want to do is crawl back into bed even though I slept fairly decently.” In context ↗ Made symptoms worse
  • Lithium orotate (low-dose)“Lithium orotate even at micro dose levels (2.5 mg, 1/4 tablet) knocked me on my butt.” In context ↗ Side effects
  • Nattokinase“I have felt worse since starting a new “Spike Protein” supplement (it has natto & several other herbal compounds)” In context ↗ Made symptoms worse
  • Duloxetine (Cymbalta)“I took it for about two weeks and then I set it aside, the low-grade GI misery just wasn’t worth it.” In context ↗ Gut side effects
  • Cannabis (THC, marijuana)“the problem is THC makes me very lazy!” In context ↗ Side effects

Symptoms mentioned

Their words about their symptoms
  • Sleep problemsthe night passes for me in a series of naps, tossing & turning In context ↗
  • Post-exertional malaiseMild to moderate PEM but anything is better then complete inactivity In context ↗
  • BreathlessnessCardiac symptoms with shortness of breath predominate In context ↗
  • Heart symptoms & palpitationsMy heart rate accelerates dramatically with even mild exertion In context ↗
  • Brain fogI am suffering from worsened brain fog with tinnitus In context ↗
  • Pain & fibromyalgiaa strange assortment of musculoskeletal aches & pains In context ↗
  • Headaches & migraineA new symptom has appeared - late night headaches In context ↗
  • Gut problemsbloating and GI misery In context ↗
  • Temperature regulationoscillating between freezing to death with a few night sweats thrown in In context ↗
  • Anxiety & low moodover past decades of struggles against chronic depression & anxiety In context ↗
  • POTS & dysautonomiaSo dysautonomia it is! In context ↗

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