Long COVID with brain fog, pain and nerve symptoms, somewhat better with NAC and CoQ10
- Condition
- Long COVID
- At worst
- Not stated
- Ill before improving or writing
- Not stated
- Last post
- Aug 2026
In their words
- Condition: Long COVID
r/covidlonghaulers
In context ↗ - Now: Somewhat better
I've had definite benefits - mostly relief from aching and drowsiness during the day ... I find it really difficult to do any of the things that might help me without it.
Read from 10 of their posts and comments; links to the 9 this page draws on
Summary
A long-COVID patient (onset not dated) described brain fog, pain, and nerve and tremor symptoms. They credited NAC and CoQ10 with improvement, later adding nattokinase, and alpha-lipoic acid, curcumin and acetyl-L-carnitine with helping severe neuropathy. Low-dose naltrexone relieved brain fog and aching but caused dysphoria and anhedonia; they settled at 0.5 mg and stayed on it, using magnesium and melatonin for sleep.
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What they tried
What they credit
Also tried
Their words about each treatment
- NAC · Helped
I got improvement from NAC too - & CoQ10 FWIW.
In context ↗ - CoQ10 · Helped
Seemed to have some positive influence on the brain fog
In context ↗ - nattokinase · Helped
So far, nattokinase, CoQ10 and NAC seem to have done good things
In context ↗ - magnesium l-threonate & glycinate · Helped
finding the right amount of magnesium l-threonate & glycinate and timing on those
In context ↗ - electrolyte mix · Helped
then getting phosphorus from an electrolyte mix
In context ↗ - Hydrozyzine · Helped
Hydrozyzine helped a little too - though it makes me sluggish
In context ↗ - Alpha-lipoic acid · Helped
Could have been been placebo effect, but seemed to really help
In context ↗ - the 6 Fs from Howard Schubiner · Helped
these 6 Fs from Howard Schubiner are helpful for me to pay attention to
In context ↗ - LDN · Helped
I've had definite benefits - mostly relief from aching and drowsiness during the day.
In context ↗ - l-theanine · Helped
I use l-theanine, melatonin, a small dose of THC and large one of CBD.
In context ↗ - inositol · Helped
Also magnesium glycinate and inositol - more just general calming a little before bed.
In context ↗ - direct sunlight · Helped
Waking up and going in direct sunlight for 5 minutes before doing anything else helps too.
In context ↗
Approaches: Anticoagulants · Supplements
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| — | Ill with long COVID; onset date not statedwas hoping supplements would help with crashes/PEMIn context ↗ | |
| 2023-09-23 | Brain fog improved on NAC and CoQ10I got improvement from NAC too - & CoQ10 FWIW.In context ↗ | NAC (N-acetylcysteine) |
| 2025-04-23 | Bad neuropathy eased on alpha-lipoic acid, curcumin and acetyl-L-carnitineCould have been been placebo effect, but seemed to really help and I was desperate.In context ↗ | |
| 2025-04-23 | Low-dose naltrexone eased brain fog and pain at 0.5-1 mgI had really hopeful reduction in brain fog and various types of pain at .5mg going up to 1mg.In context ↗ | Low-dose naltrexone |
| 2025-04-23 | Dysphoria and anhedonia on LDN; cutting the dose brought rebound mood swings and painSwitched back down to .5mg and got sudden rebound mood fluctuations & hyperalgesia (just everything hurting for a while).In context ↗ | |
| 2026-01-30 | Settled at 0.5 mg LDN with relief of aching and daytime drowsiness, at the cost of anhedoniaI've had definite benefits - mostly relief from aching and drowsiness during the day.In context ↗ | Low-dose naltrexone |
| 2026-08-28 | Sleep settled with a Medterra gummy, melatonin, L-theanine, THC and CBD2/3 of a Sound Asleep gummy from Medterra seems to be the dose I settled on after experimenting to knock out without too much grogginess in the morning.In context ↗ |
Adverse events
- Hydroxyzine (Atarax, Vistaril)“Hydrozyzine helped a little too - though it makes me sluggish, so I try to limit it and take it only before sleep.” In context ↗ Side effects
- Low-dose naltrexone“Then after a while developed some quite stark dysphoria/anhedonia” In context ↗ Mood or psychiatric effects
- Low-dose naltrexone“drinking became more complicated (hard to know how much, rough 2 day hangovers)” In context ↗ Side effects
- Low-dose naltrexone“Switched back down to .5mg and got sudden rebound mood fluctuations & hyperalgesia (just everything hurting for a while).” In context ↗ Withdrawal problems
- Low-dose naltrexone“Anhedonia (being unable to find joy in things) is a pretty rough side effect for some (including me)” In context ↗ Mood or psychiatric effects
- Low-dose naltrexone“despite the fact it has mood effects which I don't like” In context ↗ Mood or psychiatric effects
Symptoms mentioned
Their words about their symptoms
- Brain fog
I had really hopeful reduction in brain fog and various types of pain at .5mg going up to 1mg.
In context ↗ - Pain & fibromyalgia
I've had definite benefits - mostly relief from aching and drowsiness during the day.
In context ↗ - Neuropathy & tingling
I did a combo of Alpha-lipoic acid, curcumin and Acetyl-L-carnitine when my neuropathy got really bad.
In context ↗ - Sleep problems
2/3 of a Sound Asleep gummy from Medterra seems to be the dose I settled on after experimenting to knock out without too much grogginess in the morning.
In context ↗ - Post-exertional malaise
was hoping supplements would help with crashes/PEM
In context ↗ - Anxiety & low mood
Anhedonia (being unable to find joy in things) is a pretty rough side effect for some (including me)
In context ↗
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