Long COVID with migraines, brain fog and pain, much better after HRT
- Condition
- Long COVID
- At worst
- Not stated
- Ill before improving or writing
- Not stated
- Last post
- Apr 2026
In their words
- Condition: Long COVID
I've gone on hrt for long covid and perimenopause (and hEDS management) and it has been very successful for me.
In context ↗ - Now: Much better
For me and 3 other heds people with long covod symptoms, it ended up being our gallbladder. I'm acompletely different person since I got mine out in December.
In context ↗ - Began after: COVID
I've gone on hrt for long covid and perimenopause
Read from 17 of their posts and comments; links to the 10 this page draws on
Summary
Orchid 87385, in their mid-40s, has long COVID plus hEDS and 35 years of MCAS and POTS symptoms, with migraines, brain fog and pain. They credit HRT (estradiol patch and 400 mg progesterone daily) with a big improvement, and Wellbutrin with low-dose naltrexone for energy and pain. Aloe helped their joints, and an ayahuasca ceremony brought months of remission. They are a completely different person since gallbladder removal in December.
Ask Miruvor AI
What they tried
What they credit
Also tried
Their words about each treatment
- hrt (estradiol patch and progesterone pills) · Helped a lot
I've gone on hrt for long covid and perimenopause (and hEDS management) and it has been very successful for me.
In context ↗ - birth control pills · Worse
I've never been able to tolerate progesterone only bc pills. Last time I tried my knees wanted to explode within days.
In context ↗ - ayahuasca · Helped a lot
found it put my mcas, pots, and brain fog/depression into remission for several months afterwards
In context ↗ - mushrooms · Helped
I have done fine and found some relief on small doses
In context ↗ - nicotine patches · Helped
The brain fog clearing affect tends to stay for me after I wear them for 2-4 weeks
In context ↗ - wellbutrin · Helped
I've gotten a lot of relief from a combo of wellbutrin and low dose naltrexone
In context ↗ - low dose naltrexone · Helped
they helped a lot with my energy levels, acid reflux hypermobility, pain, etc.
In context ↗ - vitamin d · Not said
I'm also on hrt for perimenopause, vitamin d, methylfolate, and nac.
In context ↗ - Cusack protocol (aloe supplements) · Helped
Aloe has been proven in studies to assist fibroblasts during collagen construction and has helped my joints immensely.
In context ↗ - antibiotics · Worse
I struggle with hives a d swelling with all antibiotics
In context ↗ - steroids · Not said
immediately followed by steroids to bring me back to baseline
In context ↗ - gallbladder removal · Helped a lot
I'm acompletely different person since I got mine out in December.
In context ↗ - Progestin-only birth control (mini pill, implant or shot) · Not said
I've never been able to tolerate progesterone only bc pills. Last time I tried my knees wanted to explode within days. Couldn't walk without k taping and putting knee wraps on.
In context ↗ - Ciprofloxacin (Cipro) · Not said
I took it in 2001 and blew three discs in my spine
In context ↗
Approaches: Other antidepressants · Other drugs and medicines · Sex hormones · Surgery & structural
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| — | Long COVID on top of 35 years of MCAS and POTS symptoms with hEDSI have hEDS, and symptoms of mcas and pots for 35 years.In context ↗ | |
| pre covid | Ayahuasca ceremony; MCAS, POTS, brain fog and depression remitted for several monthsI did a ceremony pre covid and found it put my mcas, pots, and brain fog/depression into remission for several months afterwards.In context ↗ | |
| — | Strong mushroom dose left her depleted for about a weekone much stronger dose I tried at someone else's advice also fucked me up and left me depleted for about a weekIn context ↗ | |
| — | HRT (estradiol patch plus progesterone pills) after birth control pills failedI've gone on hrt for long covid and perimenopause (and hEDS management) and it has been very successful for me.In context ↗ | |
| — | Wellbutrin plus low-dose naltrexone helped energy, pain and refluxI've gotten a lot of relief from a combo of wellbutrin and low dose naltrexoneIn context ↗ | Low-dose naltrexone |
| December | Gallbladder removed; feels a completely different personI'm acompletely different person since I got mine out in December.In context ↗ | Gallbladder removal |
Adverse events
- Hormonal birth control (unspecified)“we tried to do this through birth control versions and I fell completely apart” In context ↗ Made symptoms worse
- Psilocybin (magic mushrooms)“one much stronger dose I tried at someone else's advice also fucked me up and left me depleted for about a week” In context ↗ Made symptoms worse
- Hormone replacement therapy (HRT), Hormonal birth control (unspecified)“We tried a combo birth control but it made my knees want to fall apart as I walked around” In context ↗ Side effects
- Progestin-only birth control (mini pill, implant or shot)“I've never been able to tolerate progesterone only bc pills. Last time I tried my knees wanted to explode within days. Couldn't walk without k taping and putting knee wraps on.” In context ↗ Side effects
- Ciprofloxacin (Cipro)“I took it in 2001 and blew three discs in my spine” In context ↗ Side effects
- Antibiotics (unspecified)“I struggle with hives a d swelling with all antibiotics, so we've settled on a low dose course” In context ↗ Allergic reaction / anaphylaxis
- Antibiotics (unspecified)“I struggle with hives a d swelling with all antibiotics ... I have to do the same with vaccines” In context ↗ Allergic reaction / anaphylaxis
Symptoms mentioned
Their words about their symptoms
- Brain fog
Estrogen helped a ton with brain fog, energy, and tightening connective tissue
In context ↗ - POTS & dysautonomia
symptoms of mcas and pots for 35 years
In context ↗ - Mast cell (MCAS) & allergies
I struggle with hives a d swelling with all antibiotics
In context ↗ - Pain & fibromyalgia
both wellbutrin and low dose naltrexone have been fabulous at relieving pain and tightening my joints
In context ↗ - Headaches & migraine
things got way better (migraines went away) when I got on hrt
In context ↗ - Gut problems
they helped a lot with my energy levels, acid reflux hypermobility, pain, etc.
In context ↗ - Anxiety & low mood
put my mcas, pots, and brain fog/depression into remission for several months afterwards
In context ↗
Ask Miruvor AI
Similar stories
-
ME/CFS with housebound dips, now much better on low-dose naltrexone
A Seattle lab worker who developed ME/CFS in 2008 after mono and mold exposure, she stayed mild to moderate for over a decade with housebound dips. Low-dose naltrexone in 2021, with Wellbutrin, Strattera, acyclovir and MCAS antihistamines, cleared her brain…
-
Long COVID: two years of dysautonomia and suicidal thoughts, now partly better after LDN
After getting long COVID they spent roughly two years in what they called hell, with dysautonomia and suicidal thoughts, and a year off work on sabbatical. Supplements, diet changes, rest, LDN, a stellate ganglion block, neurofeedback, somatics, fasting and…
-
ME/CFS crashes, daily pain and broken sleep, now much better after a supplement stack
Vale 55535 described ME/CFS with prolonged post-exertional crashes, daily pain and broken sleep. A supplement stack including ubiquinol, ALCAR, NA-R-ALA and B vitamins gave about 50-75% more energy and shortened PEM recovery to hours or 1-2 days; they later…
-
Long COVID brain fog, fatigue and POTS, now much better with pacing and compression
A retired Northern California woman got long COVID in Italy in October 2024, with brain fog, fatigue, tinnitus and gut trouble; POTS was diagnosed later. Low-dose naltrexone, bupropion, acupuncture, osteopathy, pacing, salt and compression brought slow…