Disabling brain fog and sensory issues in ME/CFS, somewhat better with HRT and naltrexone
- Condition
- ME/CFS
- At worst
- Not stated
- Ill before improving or writing
- Not stated
- Last post
- Aug 2026
In their words
- Condition: ME/CFS
Waiting for my appointment at a ME/cfs clinic (really hoping for LDN and meds for PoTS)
In context ↗ - Now: Somewhat better
Ik gebruik nu LDN en wow, mijn neurofatigue en sensorische overprikkeling is zóveel verbeterd!
In context ↗ - Began after: COVID
Got severe perimenopause issues and PMDD after covid-infection.
In context ↗
Summary
A Reddit user dated her perimenopause and PMDD to a covid infection, with disabling brain fog and sensory overstimulation; she was waiting for an ME/CFS clinic appointment. Bio-identical HRT eased the brain fog and sensory issues, which remained but less severe. Guanfacine calmed her overactive sympathetic nervous system and low-dose naltrexone greatly improved her neurofatigue and sensory overstimulation. She also took sertraline, dexamfetamine, melatonin and supplements.
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What they tried
What they credit
Also tried
Their words about each treatment
- Sertraline · Not said
Sertraline (ssri for sleep, low mood, anxiety, PMDD)
In context ↗ - Dexamfetamine · Helped
Dexamfetamine (ADHD meds, can't function without, maybe want to try Guanfacine instead)
In context ↗ - HRT (bio-identical) · Helped
Hormones have really helped with the disabling brainfog and sensory issues (still have them, but not as severe anymore).
In context ↗ - Citrizine · Not said
Citrizine (trying this, maybe MCAS)
In context ↗ - Melatonin · Helped
Melatonin 1,5 mg helps me with sleep.
In context ↗ - NAC · Helped
NAC (really helps with brainfog)
In context ↗ - Q10 · Helped
Q10 (also helps with brainfog)
In context ↗ - Magnesium glyvinate · Not said
Magnesium glyvinate
In context ↗ - Nattokinase · Not said
Nattokinase (against microclots)
In context ↗ - PEA · Not said
PEA (against pain)
In context ↗ - Omega 3 · Not said
Omega 3 (anti inflammatory)
In context ↗ - Multi vitamin with methylated B · Not said
Multi vitamin with methylated B (MTHFR positive)
In context ↗ - Pycnogenol · Not said
Pycnogenol and Aesculus Hippocastanum for arteries
In context ↗ - Support stockings, salt and hydration powder · Not said
I wear support stockings, use salt and hydration powder
In context ↗ - Lifted bed at the headboard · Helped
lifted my bed at the headboard (really helped with dysautonomia at night
In context ↗ - Guanfacine · Helped a lot
Guanfacine helps enormously to calm down the overactive symphatic nervous system.
In context ↗ - Mestinon · Helped
Mestinon helps to bring the parasympatic nerve system a little up.
In context ↗ - LDN · Helped a lot
Ik gebruik nu LDN en wow, mijn neurofatigue en sensorische overprikkeling is zóveel verbeterd!
In context ↗
Approaches: Stimulants
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| — | Illness followed a covid infectionGot severe perimenopause issues and PMDD after covid-infection.In context ↗ | |
| before November 2025 | Bio-identical HRT eased brain fog and sensory issuesHormones have really helped with the disabling brainfog and sensory issues (still have them, but not as severe anymore).In context ↗ | Hormone replacement therapy (HRT) |
| July 2026 | Guanfacine calmed the overactive sympathetic nervous systemGuanfacine helps enormously to calm down the overactive symphatic nervous system.In context ↗ | Guanfacine |
| August 2026 | Low-dose naltrexone greatly improved neurofatigue and sensory overstimulationIk gebruik nu LDN en wow, mijn neurofatigue en sensorische overprikkeling is zóveel verbeterd!In context ↗ | Low-dose naltrexone |
Symptoms mentioned
Their words about their symptoms
- Brain fog
Hormones have really helped with the disabling brainfog and sensory issues (still have them, but not as severe anymore).
In context ↗ - Light & noise sensitivity
mijn neurofatigue en sensorische overprikkeling is zóveel verbeterd
In context ↗ - POTS & dysautonomia
really helped with dysautonomia at night
In context ↗ - Sleep problems
Melatonin 1,5 mg helps me with sleep.
In context ↗ - Anxiety & low mood
Sertraline (ssri for sleep, low mood, anxiety, PMDD)
In context ↗ - Pain & fibromyalgia
PEA (against pain)
In context ↗ - Mast cell (MCAS) & allergies
Citrizine (trying this, maybe MCAS)
In context ↗ - Post-exertional malaise
LDN reduces PEM possibly because it lowers inflammation in the brain.
In context ↗
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