Long COVID
Moderate → much betterIll 2 years before improving or writingNeeds ongoing treatment
Long COVID with PEM and breathlessness, now much better after LDN and CoQ10
- Condition
- Long COVID
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- 2 years
- Last post
- Aug 2026
In their words
- Condition: Long COVID
Covid in June 2024 slow decline into LC as I continued to push it on exercise.
In context ↗ - At worst: Moderate
progressed to the point where I was having shortness of breath with just a short flat walk after a couple months, and would have major PEM lasting 1-2 weeks when I overdid it on exercise
In context ↗ - Now: Much better
I’m probably in the mild camp (moderate at times in the past where I was more severe) as I can work and walk and am going back to the gym, but it still sucks.
In context ↗ - Began after: COVID
got Covid again in June 2024 which really hit me hard
Read from 47 of their posts and comments; links to the 22 this page draws on
Summary
A man in his mid-20s in biomedical research developed long COVID after a COVID infection in June 2024, with PEM lasting one to two weeks, breathlessness after short walks and exercise intolerance. LDN, CoQ10, metoprolol, a carnivore diet, tadalafil and rapamycin each helped; he could work and exercise again but stayed mildly limited, and by August 2026 no longer felt he needed rapamycin.
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What they tried
What they credit
CoQ10· Helped a lot · mainLDN· Helped a lot · mainrapamycin· Helped a lot · maincarnivore diet· Helped a lottadalafil· Helped a lotmetoprolol· Helpedalbuterol· Helpedketo diet· HelpedOxaloacetate· Helpedvitamins C and E· Helpedsulforaphane· Helpedhydrogen water· Helpedpacing· Helpedtime· Helpedcreatine· Helped
Also tried
Zyrtec· HelpedPepcid· Helpedwater fasting· Helpedexercise (hikes, biking, basketball)· Worsenattokinase and lumbrokinase· Worsenattokinase and lumbrokinase· WorsePPIs· WorseMediterranean keto diet· WorseMediterranean keto diet· Worsefluoroquinolone antibiotics· Much worseacupuncture· Not saidelectrolytes (Real Salt, Morton's Lite Salt, magnesium)· Not said
Their words about each treatment
- exercise (hikes, biking, basketball) · Worse
I was exercising while I had Covid and definitely tried to do too much (hikes, biking, basketball, wakesurfing) 1-2 months after
In context ↗ - CoQ10 · Helped a lot
pretty soon after I started taking it I was able to play some decent basketball without PEM
In context ↗ - LDN · Helped a lot
Started LDN at 1mg and felt significantly better the first day
In context ↗ - nattokinase and lumbrokinase · Worse
Tried nattokinase and lumbrokinase separately, each for a about week, felt like it made me fell ill, discontinued it.
In context ↗ - metoprolol · Helped
Currently taking 12.5mg daily (low dose) and feel like it is really helping me improve my exercise tolerance
In context ↗ - rapamycin · Helped a lot
Rapamycin seems to be really really helpful for me. I did try higher doses but am sticking to 2mg/week.
In context ↗ - albuterol · Helped
Treatment: albuterol, still taking it.
In context ↗ - PPIs · Worse
I had some pretty severe difficulties with PPI's
In context ↗ - fluoroquinolone antibiotics · Much worse
I had FQ toxicity from a course of antibiotics back in Feb 2020. Really went through hell.
In context ↗ - carnivore diet · Helped a lot
Really had improved symptoms, better exercise tolerance, less shortness of breath with exercise, less PEM.
In context ↗ - Mediterranean keto diet · Worse
After about two weeks I did an exercise test at PT
In context ↗ - keto diet · Helped
This combo seems to really be helping my energy levels and reducing PEM/SOB.
In context ↗ - Oxaloacetate · Helped
I also added Oxaloacetate. This combo seems to really be helping my energy levels and reducing PEM/SOB.
In context ↗ - acupuncture · Not said
doing acupuncture with someone who actually has LC and has treated in a lot
In context ↗ - tadalafil · Helped a lot
I recently tried 5mg taladfil and it has helped a lot. I did the best running I’ve done in a year.
In context ↗ - Zyrtec · Helped
I started it, felt great so I went on a little run (zyrtec+pepcid).
In context ↗ - vitamins C and E · Helped
Yes seem to very helpful for me. CoQ10, vitamins c and e, sulforaphane, and hydrogen water
In context ↗ - electrolytes (Real Salt, Morton's Lite Salt, magnesium) · Not said
Real salt thorne magnesium and Morton’s lite salt. The holy trinity.
In context ↗ - water fasting · Helped
I’ve done a couple 2 - 3 day fasts since I’ve had LC, I feel like they helped but then I just went and exercised and induced PEM
In context ↗ - pacing · Helped
CoQ10, LDN, Rapamycin, time, pacing, creatine
In context ↗
Approaches: PDE5 inhibitors · Beta-blockers · Diet · Other drugs and medicines · Pacing · Supplements
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| June 2024 | second COVID infection, then slow decline into long COVID while still exercisingCovid in June 2024 slow decline into LC as I continued to push it on exercise.In context ↗ | Mild | |
| about two months after onset (August 2024) | breathless after a short flat walk; major PEM lasting 1-2 weeks after overdoing exerciseprogressed to the point where I was having shortness of breath with just a short flat walk after a couple months, and would have major PEM lasting 1-2 weeks when I overdid it on exercise.In context ↗ | Moderate | |
| October 2024 | started LDN, felt significantly better the first dayStarted LDN at 1mg and felt significantly better the first day, slightly bad for my sleep but just feeling noticeably better in the day timeIn context ↗ | Mild | Low-dose naltrexone |
| December 2024 | CoQ10: able to play basketball and lift weights without PEMpretty soon after I started taking it I was able to play some decent basketball without PEMIn context ↗ | Mild | CoQ10 / ubiquinol |
| February 2025 | metoprolol and albuterol added; better exercise toleranceCurrently taking 12.5mg daily (low dose) and feel like it is really helping me improve my exercise tolerance and feeling better throughout the day.In context ↗ | Mild | Metoprolol (Lopressor, Toprol) |
| April 2025 | carnivore diet for two months, best he had done symptom-wiseEventually in April 2025 I tried the carnivore diet for 2 months, probably the best I’ve done symptom-wise.In context ↗ | Mild | |
| June 2025 | off carnivore, symptoms returned; exercise test at PT triggered PEMGot tired of it and went off and symptoms pretty quickly came back (PEM, high heart rate with mild exercise, shortness of breath).In context ↗ | Mild | |
| July 2025 | restarted rapamycin (4mg/week), really helpedAdded rapamycin (4mg/week) which really helped but I was still limping through doing too much exercise and inducing PEM.In context ↗ | Mild | Rapamycin / sirolimus |
| August 2025 | big PEM episode after overdoing exercise; considered medical leaveAfter a big PEM episode in August I was not doing well and considered taking medical leave from my job.In context ↗ | Mild | |
| mid September 2025 | combined keto with rapamycin, added oxaloacetate and acupuncture; more energy, less PEM and breathlessnessThen I decided mid September to combine keto and rapamycin. I also added Oxaloacetate. This combo seems to really be helping my energy levels and reducing PEM/SOB.In context ↗ | Mild | Rapamycin / sirolimus |
| October 2025 | tadalafil helped a lot; best running in a yearI recently tried 5mg taladfil and it has helped a lot. I did the best running I’ve done in a year.In context ↗ | Mild | Tadalafil (Cialis) |
| February 2026 | PEM crash after going for a run when the antihistamines felt goodI started it, felt great so I went on a little run (zyrtec+pepcid). Big PEM crash.In context ↗ | Mild | |
| August 2026 | rapamycin helped a lot; now feels he no longer needs itbest dose for me was 2mg, every 1 to 3 weeks. for a while I was taking it every week but now I don't feel I need it anymore (tried a bunch of times).In context ↗ | Mild | Rapamycin / sirolimus |
Adverse events
- CoQ10 / ubiquinol“It gave me insomnia when I first started taking it.” In context ↗ Insomnia from treatment
- Low-dose naltrexone“Started LDN at 1mg and felt significantly better the first day, slightly bad for my sleep” In context ↗ Insomnia from treatment
- Rapamycin / sirolimus“Made me very tired and got several colds, as it was in the Winter.” In context ↗ Side effects
- Rapamycin / sirolimus“Rapamycin has made me feel tired and depleted in the past” In context ↗ Made symptoms worse
- Nattokinase“Tried nattokinase and lumbrokinase separately, each for a about week, felt like it made me fell ill, discontinued it.” In context ↗ Made symptoms worse
- Lumbrokinase“Tried nattokinase and lumbrokinase separately, each for a about week, felt like it made me fell ill, discontinued it.” In context ↗ Made symptoms worse
- Lumbrokinase“I tried lumbro fairly early on it but felt it made me feel bad so I stopped it.” In context ↗ Made symptoms worse
- Nattokinase, Lumbrokinase“So I decided to try fibrinolytics, first Nattokinase then lumbrokinase. Both give me a strange sensation and unpleasant sensation.” In context ↗ Made symptoms worse
- Antibiotics (unspecified)“I had FQ toxicity from a course of antibiotics back in Feb 2020. Really went through hell.” In context ↗ Side effects
- Proton pump inhibitors (unspecified)“I had some pretty severe difficulties with PPI's really felt like the lack of acid made my stomach cramp and thus impacted how I felt on the day to day basis.” In context ↗ Gut side effects
- Extended water fasting (3+ days)“I also find it pretty difficult to sleep well while doing a long fast” In context ↗ Insomnia from treatment
Symptoms mentioned
Brain fogBreathlessnessHeart symptoms & palpitationsPain & fibromyalgiaPost-exertional malaiseSleep problems
Their words about their symptoms
- Post-exertional malaise
would have major PEM lasting 1-2 weeks when I overdid it on exercise
In context ↗ - Breathlessness
I was having shortness of breath with just a short flat walk
In context ↗ - Heart symptoms & palpitations
high heart rate with mild exercise
In context ↗ - Pain & fibromyalgia
my calves/ankles/achilles tendons are super sore and painful for several days
In context ↗ - Brain fog
PEM, fatigue, feeling foggy
In context ↗ - Sleep problems
It gave me insomnia when I first started taking it.
In context ↗
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