Bedridden with long COVID, now much better on a low-histamine diet

Condition

Long COVID

At worst

Severe (mostly bedbound)

Ill before improving or writing

2 months

Last post

Aug 2026

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What they tried

Approaches: H1 antihistamines · H2 blockers · Antihistamines & MCAS · Diet · Mould avoidance · Supplements

Their path

What they say at each step doesn’t fit the worst point or outcome above on the severity scale, so the steps are listed as they describe them. Dates are when they posted.

Adverse events

• Nattokinase, Serrapeptase“I think either natto or streptokinase (i took them together) sent me on a downward spiral that took me months to recover from.” In context ↗ Made symptoms worse
• Nattokinase, Serrapeptase“That night I got the first signs of neurological issues and it went downhill from there--brain fog, GI problems that I never had before, eye issues, etc, insane anxiety.” In context ↗ Made symptoms worse
• Nattokinase, Serrapeptase“The initial reaction was intense anxiety and elevated heart rate (in the region of 120BPM sitting down).” In context ↗ Heart rhythm problems
• Nattokinase, Serrapeptase“But after this initial attack, many of my other symptoms got much worse, especially brain fog and derealization.” In context ↗ Made symptoms worse
• Nattokinase, Serrapeptase“It permanently lowered my baseline” In context ↗ Made symptoms worse
• Nattokinase“Nattokinase, at very very small doses made me feel a LOT worse.” In context ↗ Made symptoms worse
• Vitamin D and sun exposure“Six months ago I took about 1/10th the recommended dose of vitamin d3 and it nearly sent me to the emergency room.” In context ↗ Made symptoms worse
• Vitamin D and sun exposure“Within an hour heart rate jumped to 125, crazy anxiety, I thought I was going to die. Lasted for a few hours. Had symptoms for the next few weeks.” In context ↗ Mood or psychiatric effects
• Vitamin D and sun exposure“I tried only about 100IU of vitamin D six months ago and it made things a lot worse for me--increased heart rate, panic, anxiety.” In context ↗ Made symptoms worse
• Macrogol / polyethylene glycol (Movicol, MiraLAX, Laxido)“Was constipated, I took miralax. Made the constipation go away but then brain fog set in.” In context ↗ Made symptoms worse
• Macrogol / polyethylene glycol (Movicol, MiraLAX, Laxido)“It turned out to be caused by miralax. I discontinued the miralax and the pain went away.” In context ↗ Made symptoms worse
• Omega-3 and fish oil“I also tried fish oil capsules and those were *much much* worse.” In context ↗ Made symptoms worse
• Baicalein and quercetin“Quercetin didn't work for me. Made things worse. After about a month of that, I eventually stopped.” In context ↗ Made symptoms worse
• Nicotine patches“I tried a much smaller dose of transdermal nicotie very briefly but I got a headache almost instantly.” In context ↗ Side effects
• Low-dose naltrexone“No, at higher doses I got headaches and brain fog.” In context ↗ Side effects
• Low-dose naltrexone“0.5mg made things worse for me. I dropped to a very small dose (about 0.05mg) and stayed there for a few months during which I got noticeably better.” In context ↗ Made symptoms worse
• Low-dose naltrexone“I could never go past 0.1mg because I would gradually get worse and worse.” In context ↗ Made symptoms worse
• Low-dose naltrexone“I can't stop using LDN because if I do I go into withdrawal!” In context ↗ Withdrawal problems
• Low-dose naltrexone“Yes, I discovered that much of my sensitivity to smell was a withdrawal symptom from LDN.” In context ↗ Withdrawal problems
• Cromolyn (Gastrocrom, Nalcrom)“Cromolyn (brand name, formulated in water with no additives) did help, but gastrocrom (generic, with additives) made things worse.” In context ↗ Made symptoms worse
• Cromolyn (Gastrocrom, Nalcrom)“I'm now on 800mg daily but at the time even a single drop would cause me to almost pass out.” In context ↗ Low blood pressure or fainting
• Ketotifen (Zaditen)“I seem to be very sensitive to Ketotifen and LDN and dosages higher than those listed above begin to cause adverse effects.” In context ↗ Side effects
• Probiotics and fermented foods“My reaction to the first scoop I ever took was pretty violent, with severe brain fog, anxiety, and some fatigue.” In context ↗ Made symptoms worse
• Vitamin C“I can't take vitamin c, it gives me a terrible reaction.” In context ↗ Made symptoms worse
• Vitamin B complex“I can't take any vitamins. B vitamins are one of the worst offenders for me, for some reason.” In context ↗ Made symptoms worse
• Multivitamins (Centrum)“I react to all multivitamins. The problem with multi-ingredient supplements/foods is that if you react to one ingredient you react to the whole thing.” In context ↗ Made symptoms worse
• Magnesium“Of course I kept taking the magnesium and of course it never worked again and in fact every time I took it since it actually made everything much much worse.” In context ↗ Made symptoms worse
• Stimulants (unspecified)“Sadly, I react badly to stimulants...” In context ↗ Side effects
• “I even tried pure caffeine recently with no other additives and it was still a no.” In context ↗ Made symptoms worse
• Salt, electrolytes and fluids“For about half a year I used to drink Pedialyte because I thought--hey, electrolytes, right?--and then I stopped and realized--oh shit, I feel much better now.” In context ↗ Made symptoms worse
• “Every single supplement I tried made things worse for me, sometimes irreparably.” In context ↗ Made symptoms worse
• “told me to reintroduce foods regardless of symptoms. I tried that for a while and it was a complete disaster.” In context ↗ Made symptoms worse

Symptoms mentioned

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